The alternative siRNA-RISC loading complex (aRLC) has been characterised in S2 cells. In the aRLC, loqs replaces r2d2 as the double-stranded RNA-binding domain-containing protein. siRNA RISC-loading complex binds small interfering RNAs (siRNAs) siRNA and loads it onto AGO2 to form RNA-induced silencing complexes (RISCs). (Adapted from FBrf0237457.)