Gene Group: GTPASES

General Information

Name

GTPASES

Species

D. melanogaster

Symbol

GTPASE

FlyBase ID

FBgg0001569

Date last reviewed

2020-07-16

Number of members

146

Description

GTPases are proteins that bind and hydrolyse GTP and act as bimodal switchs that alternates between inactive GDP-bound, and active GTP-bound confirmation to trigger a cellular response. They regulate numerous cellular processes, including signal transduction, cell growth and differentiation, ribosome assembly and protein synthesis, cytoskeletal organization, nuclear transport and spindle assembly, and intracellular protein transport. (Adapted from PMID:2122258).

Notes on Group

Source Material

The GTPASES Gene Group has been compiled using the following publication(s): Shuman and Momany, 2021, Zeledon et al., 2019, Fu et al., 2017, O'Neill and Clark, 2016, Atkinson, 2015, Im et al., 2015, Krishnan et al., 2015, Findeisen et al., 2014, Puhl et al., 2014, Sandoval et al., 2014, Neisch et al., 2013, Rojas et al., 2012, Diez et al., 2011, Boto et al., 2010, Katanayeva et al., 2010, Nielsen et al., 2010, Tracy et al., 2010, Rosby et al., 2009, Deng et al., 2008, Kaplan et al., 2008, Kim et al., 2008, Pan et al., 2007, Zhang et al., 2007, Kollmar and Odronitz, 2006, Colicelli, 2004, Praefcke and McMahon, 2004, Hwa et al., 2002, Pasqualato et al., 2002, Koizumi et al., 2001, and Goldstein and Gunawardena, 2000 .

Key Gene Ontology (GO) terms

Molecular Function

GTPase activity

Biological Process

Cellular Component

Related Gene Groups

Parent group(s)

NUCLEOSIDE TRIPHOSPHATE PHOSPHATASES

Component group(s)

BETA TUBULINS

DYNAMIN-LIKE GTPASES

GPN-LOOP GTPASES