FB2026_02 , released June 18, 2026
Gene Group: CYTOCHROME P450 - CYP2 CLAN
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General Information
Name
CYTOCHROME P450 - CYP2 CLAN
Species
D. melanogaster
Symbol
CYP450-CYP2
FlyBase ID
FBgg0001694
Date last reviewed
2021-03-11
Number of members
7
Description
Description
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP2 clan includes D. melanogaster CYP18 and CYP303-307 family genes. CYP2 members have diverse roles and are widely considered as "environmental response genes" in mammalian species. (Adapted from FBrf0248421.)
Notes on Group

Three cytochrome P450 CYP2 clan members, phm (Cyp306a1), spo (Cyp307a1), spok (Cyp307a2), are known as 'Halloween genes' whose products are involved in the ecdysteroid biosynthetic pathway (FBrf0201926).

Source Material
The CYTOCHROME P450 - CYP2 CLAN Gene Group has been compiled using the following publication(s): Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, and Tijet et al., 2001 .
Key Gene Ontology (GO) terms
Molecular Function
monooxygenase activity
Biological Process
Cellular Component
Related Gene Groups
Parent group(s)
CYTOCHROME P450
Members (7)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
CYP450-CYP2
CYP2
CYTOCHROME P450 - CYP2 CLAN
Secondary FlyBase ID(s)
References (5)