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Feyereisen, R. (2012). Insect CYP Genes and P450 Enzymes.  Gilbert, 2012 (): 236--316.
FlyBase ID
FBrf0248421
Publication Type
Review
Abstract

This chapter discusses the insect CYP genes and P450 enzymes. Cytochrome P450, or CYP genes, constitutes one of the largest family of genes, with representatives in virtually all living organisms, from bacteria to protists, plants, fungi, and animals. The multiple functions of insect P450 enzymes, their complex biochemistry, and their toxicological and physiological importance are presented. Physiological functions are not restricted to one branch of the P450 evolutionary tree, and the ramifications that seem typical of “environmental response genes” are found in both microsomal and mitochondrial P450 encoding genes. The CYP3 and CYP4 clans seem the most diverse, and the smaller CYP2 and mitochondrial CYP clans seem to have proportionally more genes found as orthologs across species. There are many physiological functions for P450s that just are not known or suspected. CYP4C7 was shown to be selectively expressed in the corpora allata and to metabolize JH and its precursors to new metabolites.

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    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Book
    Abbreviation
    Gilbert, 2012
    Title
    Insect molecular biology and biochemistry (1st edition)
    Publication Year
    2012
    ISBN/ISSN
    9780123847478
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