FB2025_05 , released December 11, 2025
Gene: Dmel\Cyp4e2
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General Information
Symbol
Dmel\Cyp4e2
Species
D. melanogaster
Name
Cytochrome P450 4e2
Annotation Symbol
CG2060
Feature Type
protein_coding_gene
FlyBase ID
FBgn0014469
Gene Model Status
Current
Stock Availability
9 publicly available
Gene Summary
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides. (UniProt, Q27606)
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

P450

Key Links
Genomic Location
Cytogenetic map
44D1-44D1
Sequence location
Recombination map
2-59
RefSeq locus
NT_033778 REGION:8444560..8447164
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (5 terms)
Molecular Function (4 terms)
Biological Process (0 terms)
Terms Based on Experimental Evidence (0 terms)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the cytochrome P450 family. (Q27606)
Protein Signatures (InterPro)
Summaries
Gene Group (FlyBase)
CYTOCHROME P450 - CYP4 CLAN -
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The CYP4 clan includes D. melanogaster CYP4, 311-313, 316 and 318 family genes. Few CYP4 enzymes have been characterized, though some CYP4 genes are inducible by xenobiotics. (Adapted from FBrf0248421.)
Protein Function (UniProtKB)
May be involved in the metabolism of insect hormones and in the breakdown of synthetic insecticides.
(UniProt, Q27606)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Cyp4e2 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q27606)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Cyp4e2-RA
FBtr0088745
NM_057769
1783
526
Cyp4e2-RB
FBtr0339278
NM_001299267
1880
526
Additional Transcript Data and Comments
Reported size (kB)

1.458 (longest cDNA)

(Pittendrigh et al., 1996)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Cyp4e2-PA
FBpp0087824
60.7
526
9.24
Q27606
NP_477117
AAF59091
Cyp4e2-PB
FBpp0308387
60.7
526
9.24
Q27606
NP_001286196
AHN55994
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

526 aa isoforms: Cyp4e2-PA, Cyp4e2-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

485 (aa)

(Pittendrigh et al., 1996)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp4e2 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.24

Transcript Expression
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp4e2 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 1-3
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 6 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Cyp4e2
Transgenic constructs containing regulatory region of Cyp4e2
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel7096
(Ryder, 2004.4.26)
Inferred from location ( 6 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (37)
Hsap\CYP4V2
9 of 14
Yes
No
Hsap\CYP4A11
7 of 14
No
Yes
Hsap\CYP4A22
7 of 14
No
Yes
Hsap\CYP4B1
7 of 14
No
Yes
Hsap\CYP4F2
7 of 14
No
Yes
Hsap\CYP4F3
7 of 14
No
Yes
Hsap\CYP4F8
7 of 14
No
Yes
Hsap\CYP4F11
7 of 14
No
Yes
Hsap\CYP4F12
7 of 14
No
Yes
Hsap\CYP4F22
7 of 14
No
Yes
Hsap\CYP4X1
6 of 14
No
Yes
Hsap\CYP4Z1
6 of 14
No
Yes
Hsap\CYP19A1
4 of 14
No
Yes
Hsap\CYP4Z2P
3 of 14
No
Yes
Hsap\CYP3A4
2 of 14
No
No
1  
Hsap\CYP3A5
2 of 14
No
No
Hsap\CYP3A7-CYP3A51P
2 of 14
No
No
Hsap\CYP3A7
2 of 14
No
No
Hsap\CYP3A43
2 of 14
No
No
Hsap\CYP11A1
2 of 14
No
No
Hsap\CYP46A1
2 of 14
No
Yes
Hsap\TBXAS1
2 of 14
No
No
Hsap\CYP2E1
1 of 14
No
No
Hsap\CYP2J2
1 of 14
No
No
Hsap\CYP2U1
1 of 14
No
No
Hsap\CYP2W1
1 of 14
No
No
Hsap\CYP11B1
1 of 14
No
No
Hsap\CYP11B2
1 of 14
No
No
Hsap\CYP21A2
1 of 14
No
No
Hsap\CYP24A1
1 of 14
No
No
1  
Hsap\CYP26A1
1 of 14
No
No
Hsap\CYP26B1
1 of 14
No
No
Hsap\CYP26C1
1 of 14
No
Yes
Hsap\CYP27A1
1 of 14
No
No
Hsap\CYP27B1
1 of 14
No
No
Hsap\CYP27C1
1 of 14
No
No
Hsap\CYP51A1
1 of 14
No
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (38)
Rnor\Cyp4v3
9 of 14
Yes
No
Rnor\Cyp4a2
7 of 14
No
Yes
Rnor\Cyp4a8
7 of 14
No
Yes
Rnor\Cyp4b1
7 of 14
No
Yes
Rnor\Cyp4f1
7 of 14
No
Yes
Rnor\Cyp4f4
7 of 14
No
Yes
Rnor\Cyp4f6
7 of 14
No
Yes
Rnor\Cyp4f17
7 of 14
No
Yes
Rnor\Cyp4f18
7 of 14
No
Yes
Rnor\Cyp4f39
7 of 14
No
Yes
Rnor\Cyp4f40
7 of 14
No
Yes
Rnor\Cyp4a1
6 of 14
No
Yes
Rnor\Cyp4a3
6 of 14
No
Yes
Rnor\Cyp4f5
6 of 14
No
No
Rnor\Cyp4x1
6 of 14
No
Yes
Rnor\Cyp4f37
5 of 14
No
No
Rnor\Cyp19a1
3 of 14
No
No
Rnor\Cyp3a2
2 of 14
No
No
Rnor\Cyp3a9
2 of 14
No
No
Rnor\Cyp3a18
2 of 14
No
No
Rnor\Cyp3a23-3a1
2 of 14
No
No
Rnor\Cyp3a62
2 of 14
No
No
Rnor\Cyp11a1
2 of 14
No
No
Rnor\Cyp46a1
2 of 14
No
Yes
Rnor\Cyp2j16
1 of 14
No
No
Rnor\Cyp3a71-ps
1 of 14
No
Yes
Rnor\Cyp11b1
1 of 14
No
Yes
Rnor\Cyp11b2
1 of 14
No
No
Rnor\Cyp11b3
1 of 14
No
No
Rnor\Cyp24a1
1 of 14
No
No
Rnor\Cyp26a1
1 of 14
No
Yes
Rnor\Cyp26b1
1 of 14
No
Yes
Rnor\Cyp26c1
1 of 14
No
Yes
Rnor\Cyp27a1
1 of 14
No
No
Rnor\Cyp27b1
1 of 14
No
No
Rnor\LOC680316
1 of 14
No
Yes
Rnor\LOC103692784
1 of 14
No
Yes
Rnor\Tbxas1
1 of 14
No
No
Mus musculus (laboratory mouse) (46)
Mmus\Cyp4v3
9 of 14
Yes
No
Mmus\Cyp4a12a
7 of 14
No
Yes
Mmus\Cyp4a12b
7 of 14
No
Yes
Mmus\Cyp4a14
7 of 14
No
Yes
Mmus\Cyp4a29
7 of 14
No
Yes
Mmus\Cyp4a30b
7 of 14
No
Yes
Mmus\Cyp4a31
7 of 14
No
Yes
Mmus\Cyp4a32
7 of 14
No
Yes
Mmus\Cyp4b1
7 of 14
No
Yes
Mmus\Cyp4f13
7 of 14
No
Yes
Mmus\Cyp4f14
7 of 14
No
Yes
Mmus\Cyp4f15
7 of 14
No
Yes
Mmus\Cyp4f17
7 of 14
No
Yes
Mmus\Cyp4f18
7 of 14
No
Yes
Mmus\Cyp4f39
7 of 14
No
Yes
Mmus\Cyp4f40
7 of 14
No
Yes
Mmus\Cyp4a10
6 of 14
No
Yes
Mmus\Cyp4f16
6 of 14
No
No
Mmus\Cyp4f37
6 of 14
No
No
Mmus\Cyp4x1
6 of 14
No
Yes
Mmus\Cyp3a57
3 of 14
No
No
Mmus\Cyp19a1
3 of 14
No
No
Mmus\Cyp3a11
2 of 14
No
No
Mmus\Cyp3a13
2 of 14
No
No
Mmus\Cyp3a16
2 of 14
No
No
Mmus\Cyp3a25
2 of 14
No
No
Mmus\Cyp3a41a
2 of 14
No
No
Mmus\Cyp3a41b
2 of 14
No
No
Mmus\Cyp3a44
2 of 14
No
No
Mmus\Cyp3a59
2 of 14
No
No
Mmus\Cyp46a1
2 of 14
No
Yes
Mmus\Cyp2c67
1 of 14
No
No
Mmus\Cyp2c69
1 of 14
No
No
Mmus\Cyp2j8
1 of 14
No
No
Mmus\Cyp2j11
1 of 14
No
No
Mmus\Cyp11a1
1 of 14
No
No
Mmus\Cyp11b1
1 of 14
No
No
Mmus\Cyp11b2
1 of 14
No
No
Mmus\Cyp17a1
1 of 14
No
No
Mmus\Cyp24a1
1 of 14
No
No
Mmus\Cyp26a1
1 of 14
No
Yes
Mmus\Cyp26b1
1 of 14
No
Yes
Mmus\Cyp26c1
1 of 14
No
Yes
Mmus\Cyp27a1
1 of 14
No
No
Mmus\Cyp27b1
1 of 14
No
No
Mmus\Tbxas1
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (37)
Xtro\XB980013
4 of 13
Yes
Yes
Xtro\XB5810926
4 of 13
Yes
Yes
Xtro\cyp4b1.2
3 of 13
No
Yes
Xtro\cyp4f22
3 of 13
No
Yes
Xtro\cyp4v2.2
3 of 13
No
No
Xtro\cyp19a1
2 of 13
No
Yes
Xtro\cyp1c1
1 of 13
No
No
Xtro\cyp1d1
1 of 13
No
No
Xtro\cyp2a6.1
1 of 13
No
No
Xtro\cyp2a6.3
1 of 13
No
No
Xtro\cyp2a6.8
1 of 13
No
No
Xtro\cyp2a6.9
1 of 13
No
No
Xtro\cyp2c8l
1 of 13
No
No
Xtro\cyp4b1
1 of 13
No
No
Xtro\cyp4f2
1 of 13
No
Yes
Xtro\cyp4v2.1
1 of 13
No
No
Xtro\cyp11a1
1 of 13
No
No
Xtro\cyp24a1
1 of 13
No
No
Xtro\cyp26a1
1 of 13
No
No
Xtro\cyp26b1
1 of 13
No
No
Xtro\cyp26c1
1 of 13
No
Yes
Xtro\cyp27b1
1 of 13
No
No
Xtro\cyp46a1.3
1 of 13
No
No
Xtro\efs
1 of 13
No
No
Xtro\il17d
1 of 13
No
No
Xtro\LOC100487846
1 of 13
No
No
Xtro\LOC100488078
1 of 13
No
Yes
Xtro\LOC100491603
1 of 13
No
No
Xtro\LOC100497899
1 of 13
No
No
Xtro\LOC100498621
1 of 13
No
No
Xtro\LOC101731070
1 of 13
No
No
Xtro\LOC116407844
1 of 13
No
No
Xtro\runx1
1 of 13
No
No
Xtro\XB1001094
1 of 13
No
No
Xtro\XB5864179
1 of 13
No
Yes
Xtro\XB5880541
1 of 13
No
No
Xtro\XB5919979
1 of 13
No
No
Danio rerio (Zebrafish) (32)
Drer\cyp4v8
9 of 14
Yes
No
Drer\cyp4v7
8 of 14
No
No
Drer\cyp4t8
7 of 14
No
Yes
Drer\cyp4f3
3 of 14
No
No
Drer\cyp19a1a
3 of 14
No
No
Drer\cyp46a1.3
3 of 14
No
Yes
Drer\zgc:123299
3 of 14
No
Yes
Drer\cyp3c3
2 of 14
No
No
Drer\cyp11a1
2 of 14
No
No
Drer\cyp11a2
2 of 14
No
No
Drer\cyp11c1
2 of 14
No
No
Drer\cyp27b1
2 of 14
No
No
Drer\cyp46a1.2
2 of 14
No
Yes
Drer\cyp46a1.4
2 of 14
No
Yes
Drer\tbxas1
2 of 14
No
No
Drer\cyp2j20
1 of 14
No
No
Drer\cyp2p7
1 of 14
No
No
Drer\cyp3a65
1 of 14
No
No
Drer\cyp3c1
1 of 14
No
No
Drer\cyp3c4
1 of 14
No
No
Drer\cyp19a1b
1 of 14
No
Yes
Drer\cyp24a1
1 of 14
No
No
Drer\cyp26a1
1 of 14
No
Yes
Drer\cyp26b1
1 of 14
No
Yes
Drer\cyp26c1
1 of 14
No
Yes
Drer\cyp27a1.2
1 of 14
No
No
Drer\cyp27a1.4
1 of 14
No
No
Drer\cyp27a7
1 of 14
No
No
Drer\cyp27c1
1 of 14
No
No
Drer\si:ch211-113j14.1
1 of 14
No
No
Drer\si:dkey-91i10.3
1 of 14
No
No
Drer\zgc:136333
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\cyp-31A2
9 of 14
Yes
No
Cele\cyp-31A3
9 of 14
Yes
No
Cele\cyp-29A3
8 of 14
No
No
Cele\cyp-29A4
8 of 14
No
No
Cele\cyp-32A1
8 of 14
No
No
Cele\cyp-37A1
8 of 14
No
No
Cele\cyp-29A2
7 of 14
No
No
Cele\cyp-32B1
7 of 14
No
No
Cele\cyp-37B1
7 of 14
No
No
Cele\cyp-42A1
7 of 14
No
No
Cele\cyp-31A5
6 of 14
No
No
Cele\cyp-13A1
2 of 14
No
No
Cele\cyp-13A2
2 of 14
No
No
Cele\cyp-13A3
2 of 14
No
No
Cele\cyp-13A4
2 of 14
No
No
Cele\cyp-13A5
2 of 14
No
No
Cele\cyp-13A6
2 of 14
No
No
Cele\cyp-13A7
2 of 14
No
No
Cele\cyp-13A8
2 of 14
No
No
Cele\cyp-13A10
2 of 14
No
No
Cele\cyp-13A11
2 of 14
No
No
Cele\cyp-13A12
2 of 14
No
No
Cele\cyp-13B1
2 of 14
No
No
Cele\cyp-13B2
2 of 14
No
No
Cele\cyp-25A1
2 of 14
No
No
Cele\cyp-25A2
2 of 14
No
No
Cele\cyp-25A3
2 of 14
No
No
Cele\cyp-25A4
2 of 14
No
No
Cele\cyp-25A6
2 of 14
No
No
Cele\cyp-33C2
1 of 14
No
No
Cele\cyp-33E1
1 of 14
No
No
Cele\cyp-33E2
1 of 14
No
No
Cele\cyp-34A1
1 of 14
No
No
Cele\cyp-34A5
1 of 14
No
No
Cele\cyp-34A6
1 of 14
No
No
Cele\cyp-34A7
1 of 14
No
No
Cele\cyp-35A4
1 of 14
No
No
Cele\cyp-35D1
1 of 14
No
No
Cele\cyp-44A1
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (85)
Agam\AgaP_AGAP000088
7 of 12
Yes
Yes
Agam\AgaP_AGAP001861
7 of 12
Yes
Yes
Agam\AgaP_AGAP001864
7 of 12
Yes
Yes
Agam\AgaP_AGAP002418
7 of 12
Yes
No
Agam\AgaP_AGAP008356
7 of 12
Yes
Yes
Agam\AgaP_AGAP008358
7 of 12
Yes
Yes
Agam\AgaP_AGAP008552
7 of 12
Yes
Yes
Agam\AgaP_AGAP012957
7 of 12
Yes
No
Agam\AgaP_AGAP013241
7 of 12
Yes
No
Agam\AgaP_AGAP013305
7 of 12
Yes
Yes
Agam\AgaP_AGAP013490
7 of 12
Yes
Yes
Agam\AgaP_AGAP000192
6 of 12
No
No
Agam\AgaP_AGAP000193
6 of 12
No
No
Agam\AgaP_AGAP000194
6 of 12
No
No
Agam\AgaP_AGAP002419
6 of 12
No
No
Agam\AgaP_AGAP009240
6 of 12
No
No
Agam\AgaP_AGAP009241
6 of 12
No
No
Agam\AgaP_AGAP009246
6 of 12
No
No
Agam\AgaP_AGAP010414
6 of 12
No
No
Agam\AgaP_AGAP013224
6 of 12
No
Yes
Agam\AgaP_AGAP001076
5 of 12
No
No
Agam\AgaP_AGAP002417
5 of 12
No
No
Agam\AgaP_AGAP006047
5 of 12
No
No
Agam\AgaP_AGAP006048
5 of 12
No
No
Agam\AgaP_AGAP006049
5 of 12
No
No
Agam\AgaP_AGAP000877
4 of 12
No
No
Agam\AgaP_AGAP002202
4 of 12
No
No
Agam\AgaP_AGAP002205
4 of 12
No
No
Agam\AgaP_AGAP002207
4 of 12
No
No
Agam\AgaP_AGAP002416
4 of 12
No
Yes
Agam\AgaP_AGAP008553
4 of 12
No
Yes
Agam\AgaP_AGAP009696
4 of 12
No
No
Agam\AgaP_AGAP002138
3 of 12
No
No
Agam\AgaP_AGAP002195
3 of 12
No
No
Agam\AgaP_AGAP002196
3 of 12
No
No
Agam\AgaP_AGAP002197
3 of 12
No
No
Agam\AgaP_AGAP002206
3 of 12
No
No
Agam\AgaP_AGAP002208
3 of 12
No
No
Agam\AgaP_AGAP002209
3 of 12
No
No
Agam\AgaP_AGAP002211
3 of 12
No
No
Agam\AgaP_AGAP003608
3 of 12
No
No
Agam\AgaP_AGAP001443
2 of 12
No
No
Agam\AgaP_AGAP002204
2 of 12
No
No
Agam\AgaP_AGAP002210
2 of 12
No
No
Agam\AgaP_AGAP002555
2 of 12
No
No
Agam\AgaP_AGAP002870
2 of 12
No
No
Agam\AgaP_AGAP012292
2 of 12
No
No
Agam\AgaP_AGAP013511
2 of 12
No
No
Agam\AgaP_AGAP000284
1 of 12
No
No
Agam\AgaP_AGAP002429
1 of 12
No
No
Agam\AgaP_AGAP002865
1 of 12
No
No
Agam\AgaP_AGAP002866
1 of 12
No
No
Agam\AgaP_AGAP002868
1 of 12
No
No
Agam\AgaP_AGAP002869
1 of 12
No
No
Agam\AgaP_AGAP003343
1 of 12
No
No
Agam\AgaP_AGAP005774
1 of 12
No
No
Agam\AgaP_AGAP005992
1 of 12
No
No
Agam\AgaP_AGAP006082
1 of 12
No
No
Agam\AgaP_AGAP008018
1 of 12
No
No
Agam\AgaP_AGAP008019
1 of 12
No
No
Agam\AgaP_AGAP008020
1 of 12
No
No
Agam\AgaP_AGAP008021
1 of 12
No
No
Agam\AgaP_AGAP008022
1 of 12
No
No
Agam\AgaP_AGAP008203
1 of 12
No
No
Agam\AgaP_AGAP008204
1 of 12
No
No
Agam\AgaP_AGAP008206
1 of 12
No
No
Agam\AgaP_AGAP008207
1 of 12
No
No
Agam\AgaP_AGAP008208
1 of 12
No
No
Agam\AgaP_AGAP008209
1 of 12
No
No
Agam\AgaP_AGAP008212
1 of 12
No
No
Agam\AgaP_AGAP008213
1 of 12
No
No
Agam\AgaP_AGAP008214
1 of 12
No
No
Agam\AgaP_AGAP008217
1 of 12
No
No
Agam\AgaP_AGAP009363
1 of 12
No
No
Agam\AgaP_AGAP010966
1 of 12
No
No
Agam\AgaP_AGAP011028
1 of 12
No
No
Agam\AgaP_AGAP011029
1 of 12
No
No
Agam\AgaP_AGAP012294
1 of 12
No
No
Agam\AgaP_AGAP012296
1 of 12
No
No
Agam\AgaP_AGAP012800
1 of 12
No
No
Agam\AgaP_AGAP013128
1 of 12
No
No
Agam\CYP6P4
1 of 12
No
No
Agam\CYP6Z1
1 of 12
No
No
Agam\CYP6Z2
1 of 12
No
No
Agam\CYP9L1
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (129)
Atha\CYP97A3
7 of 13
Yes
No
Atha\CYP97B3
7 of 13
Yes
Yes
Atha\CYP715A1
6 of 13
No
Yes
Atha\LUT1
6 of 13
No
No
Atha\BAS1
5 of 13
No
Yes
Atha\CYP72A7
5 of 13
No
Yes
Atha\CYP72A8
5 of 13
No
Yes
Atha\CYP72A9
5 of 13
No
Yes
Atha\CYP72A10
5 of 13
No
Yes
Atha\CYP72A11
5 of 13
No
Yes
Atha\CYP72A13
5 of 13
No
Yes
Atha\CYP72A14
5 of 13
No
Yes
Atha\CYP72A15
5 of 13
No
Yes
Atha\CYP72C1
5 of 13
No
Yes
Atha\CYP96A1
5 of 13
No
Yes
Atha\CYP96A4
5 of 13
No
Yes
Atha\CYP96A5
5 of 13
No
Yes
Atha\CYP96A10
5 of 13
No
Yes
Atha\CYP96A11
5 of 13
No
Yes
Atha\CYP96A12
5 of 13
No
Yes
Atha\CYP96A15
5 of 13
No
Yes
Atha\CYP704A2
5 of 13
No
No
Atha\CYP709B1
5 of 13
No
No
Atha\CYP709B2
5 of 13
No
No
Atha\CYP709B3
5 of 13
No
No
Atha\CYP714A1
5 of 13
No
No
Atha\CYP714A2
5 of 13
No
Yes
Atha\CYP735A1
5 of 13
No
Yes
Atha\CYP735A2
5 of 13
No
Yes
Atha\AT5G08250
4 of 13
No
No
Atha\CYP86A1
4 of 13
No
No
Atha\CYP86A2
4 of 13
No
No
Atha\CYP86A4
4 of 13
No
No
Atha\CYP86A7
4 of 13
No
No
Atha\CYP86A8
4 of 13
No
No
Atha\CYP86B1
4 of 13
No
No
Atha\CYP86C1
4 of 13
No
No
Atha\CYP86C3
4 of 13
No
No
Atha\CYP94B1
4 of 13
No
No
Atha\CYP94B3
4 of 13
No
No
Atha\CYP94C1
4 of 13
No
No
Atha\CYP94D1
4 of 13
No
No
Atha\CYP94D2
4 of 13
No
No
Atha\CYP96A2
4 of 13
No
Yes
Atha\CYP96A3
4 of 13
No
Yes
Atha\CYP96A8
4 of 13
No
Yes
Atha\CYP96A13
4 of 13
No
Yes
Atha\CYP704A1
4 of 13
No
No
Atha\CYP704B1
4 of 13
No
No
Atha\CYP721A1
4 of 13
No
Yes
Atha\CYP86C2
3 of 13
No
No
Atha\CYP86C4
3 of 13
No
No
Atha\CYP94B2
3 of 13
No
No
Atha\CYP711A1
3 of 13
No
No
Atha\AT1G73340
2 of 13
No
Yes
Atha\AT3G44970
2 of 13
No
Yes
Atha\CPD
2 of 13
No
Yes
Atha\CYP71A18
2 of 13
No
No
Atha\CYP87A2
2 of 13
No
Yes
Atha\CYP96A9
2 of 13
No
Yes
Atha\CYP702A1
2 of 13
No
Yes
Atha\CYP702A3
2 of 13
No
Yes
Atha\CYP702A5
2 of 13
No
Yes
Atha\CYP702A6
2 of 13
No
Yes
Atha\CYP702A8
2 of 13
No
Yes
Atha\AT2G12190
1 of 13
No
No
Atha\AT5G36130
1 of 13
No
Yes
Atha\AT5G51900
1 of 13
No
No
Atha\BR6OX1
1 of 13
No
Yes
Atha\BR6OX2
1 of 13
No
Yes
Atha\CYP71A12
1 of 13
No
No
Atha\CYP71A13
1 of 13
No
No
Atha\CYP71A14
1 of 13
No
No
Atha\CYP71A15
1 of 13
No
No
Atha\CYP71A19
1 of 13
No
No
Atha\CYP71A20
1 of 13
No
No
Atha\CYP71A22
1 of 13
No
No
Atha\CYP71A23
1 of 13
No
No
Atha\CYP71A25
1 of 13
No
No
Atha\CYP71A26
1 of 13
No
No
Atha\CYP71A27
1 of 13
No
No
Atha\CYP71B13
1 of 13
No
No
Atha\CYP71B14
1 of 13
No
No
Atha\CYP71B21
1 of 13
No
No
Atha\CYP76C1
1 of 13
No
No
Atha\CYP76C2
1 of 13
No
No
Atha\CYP76C3
1 of 13
No
No
Atha\CYP76C4
1 of 13
No
No
Atha\CYP76C7
1 of 13
No
No
Atha\CYP77A9
1 of 13
No
No
Atha\CYP79A2
1 of 13
No
No
Atha\CYP81F3
1 of 13
No
No
Atha\CYP81G1
1 of 13
No
No
Atha\CYP82C2
1 of 13
No
No
Atha\CYP82C4
1 of 13
No
No
Atha\CYP82G1
1 of 13
No
No
Atha\CYP83A1
1 of 13
No
No
Atha\CYP83B1
1 of 13
No
No
Atha\CYP88A3
1 of 13
No
No
Atha\CYP90D1
1 of 13
No
No
Atha\CYP91A2
1 of 13
No
No
Atha\CYP93D1
1 of 13
No
No
Atha\CYP96A14P
1 of 13
No
Yes
Atha\CYP702A2
1 of 13
No
Yes
Atha\CYP703A2
1 of 13
No
No
Atha\CYP705A27
1 of 13
No
No
Atha\CYP706A6
1 of 13
No
No
Atha\CYP707A1
1 of 13
No
No
Atha\CYP707A2
1 of 13
No
No
Atha\CYP707A3
1 of 13
No
No
Atha\CYP707A4
1 of 13
No
No
Atha\CYP708A1
1 of 13
No
Yes
Atha\CYP708A2
1 of 13
No
No
Atha\CYP710A1
1 of 13
No
No
Atha\CYP710A2
1 of 13
No
No
Atha\CYP710A3
1 of 13
No
No
Atha\CYP710A4
1 of 13
No
No
Atha\CYP712A1
1 of 13
No
No
Atha\CYP712A2
1 of 13
No
No
Atha\CYP716A1
1 of 13
No
No
Atha\CYP716A2
1 of 13
No
No
Atha\CYP718
1 of 13
No
Yes
Atha\CYP722A1
1 of 13
No
No
Atha\CYP724A1
1 of 13
No
No
Atha\DWF4
1 of 13
No
Yes
Atha\KAO2
1 of 13
No
No
Atha\ROT3
1 of 13
No
Yes
Atha\TT7
1 of 13
No
No
Atha\UNE9
1 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\ERG5
3 of 13
Yes
No
Scer\DIT2
2 of 13
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\erg11
2 of 12
Yes
No
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Cyp4e2. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (73)
Cyp4e1
12 of 13
Cyp4e3
12 of 13
Cyp4ad1
11 of 13
Cyp4c3
11 of 13
Cyp4d2
11 of 13
Cyp4s3
11 of 13
Cyp4aa1
10 of 13
Cyp4ae1
10 of 13
Cyp4d1
10 of 13
Cyp4d8
10 of 13
Cyp4d14
10 of 13
Cyp4d20
10 of 13
Cyp4d21
10 of 13
Cyp312a1
10 of 13
Cyp4ac1
9 of 13
Cyp4ac2
9 of 13
Cyp4ac3
9 of 13
Cyp4p1
9 of 13
Cyp4p3
9 of 13
Cyp4g1
8 of 13
Cyp4p2
8 of 13
Cyp311a1
8 of 13
Cyp4g15
7 of 13
Cyp316a1
7 of 13
Cyp313a1
5 of 13
Cyp313b1
5 of 13
Cyp313a4
4 of 13
Cyp6a23
3 of 13
Cyp313a2
3 of 13
Cyp313a3
3 of 13
Cyp313a5
3 of 13
Cyp318a1
3 of 13
Cyp6a2
2 of 13
Cyp6a8
2 of 13
Cyp6a9
2 of 13
Cyp6a13
2 of 13
Cyp6a14
2 of 13
Cyp6a16
2 of 13
Cyp6a17
2 of 13
Cyp6a18
2 of 13
Cyp6a19
2 of 13
Cyp6a20
2 of 13
Cyp6a21
2 of 13
Cyp6w1
2 of 13
Cyp9b2
2 of 13
Cyp9c1
2 of 13
Cyp9f2
2 of 13
Cyp9h1
2 of 13
sad
2 of 13
Cyp6a22
1 of 13
Cyp6d4
1 of 13
Cyp6d5
1 of 13
Cyp6g1
1 of 13
Cyp6t1
1 of 13
Cyp6t3
1 of 13
Cyp6v1
1 of 13
Cyp9b1
1 of 13
Cyp9f3
1 of 13
Cyp12a4
1 of 13
Cyp12a5
1 of 13
Cyp12b2
1 of 13
Cyp12c1
1 of 13
Cyp12d1-d
1 of 13
Cyp12d1-p
1 of 13
Cyp12e1
1 of 13
Cyp18a1
1 of 13
Cyp28a5
1 of 13
Cyp28d2
1 of 13
Cyp49a1
1 of 13
Cyp301a1
1 of 13
Cyp309a2
1 of 13
dib
1 of 13
shd
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 2 )
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CYP4V2; cytochrome P450 family 4 subfamily V member 2
    9 of 14
    608614
    CYP4A11; cytochrome P450 family 4 subfamily A member 11
    7 of 14
    601310
        CYP4A22; cytochrome P450 family 4 subfamily A member 22
        7 of 14
        615341
            CYP4B1; cytochrome P450 family 4 subfamily B member 1
            7 of 14
            124075
                CYP4F2; cytochrome P450 family 4 subfamily F member 2
                7 of 14
                604426
                    CYP4F3; cytochrome P450 family 4 subfamily F member 3
                    7 of 14
                    601270
                        CYP4F8; cytochrome P450 family 4 subfamily F member 8
                        7 of 14
                        611545
                            CYP4F11; cytochrome P450 family 4 subfamily F member 11
                            7 of 14
                            611517
                                CYP4F12; cytochrome P450 family 4 subfamily F member 12
                                7 of 14
                                611485
                                    CYP4F22; cytochrome P450 family 4 subfamily F member 22
                                    7 of 14
                                    611495
                                    CYP4X1; cytochrome P450 family 4 subfamily X member 1
                                    6 of 14
                                    614999
                                        CYP4Z1; cytochrome P450 family 4 subfamily Z member 1
                                        6 of 14
                                        618953
                                            CYP19A1; cytochrome P450 family 19 subfamily A member 1
                                            4 of 14
                                            107910
                                              CYP4Z2P; cytochrome P450 family 4 subfamily Z member 2, pseudogene
                                              3 of 14
                                              618954
                                                  Functional Complementation Data
                                                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                                                  Interactions
                                                  Summary of Physical Interactions
                                                  Summary of Genetic Interactions
                                                  Interaction Browsers
                                                  Starting gene(s)
                                                  Interaction type
                                                  Interacting gene(s)
                                                  Reference
                                                  Starting gene(s)
                                                  Interaction type
                                                  Interacting gene(s)
                                                  Reference
                                                  External Data
                                                  Linkouts
                                                  BioGRID - A database of protein and genetic interactions.
                                                  DroID - A comprehensive database of gene and protein interactions.
                                                  MIST (protein-protein) - An integrated Molecular Interaction Database
                                                  Pathways
                                                  Signaling Pathways (FlyBase)
                                                  Metabolic Pathways
                                                  FlyBase
                                                  External Links
                                                  Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                  External Data
                                                  Linkouts
                                                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                  Class of Gene
                                                  Genomic Location and Detailed Mapping Data
                                                  Chromosome (arm)
                                                  2R
                                                  Recombination map
                                                  2-59
                                                  Cytogenetic map
                                                  44D1-44D1
                                                  Sequence location
                                                  FlyBase Computed Cytological Location
                                                  Cytogenetic map
                                                  Evidence for location
                                                  44D1-44D1
                                                  Limits computationally determined from genome sequence between P{lacW}Rs1k09514&P{lacW}l(2)k03110k03110 and P{lacW}Vps25k08904&P{lacW}ptck02507
                                                  Experimentally Determined Cytological Location
                                                  Cytogenetic map
                                                  Notes
                                                  References
                                                  44D-44D
                                                  (Dunkov, 2000.6.29)
                                                  44D1-44D2
                                                  (Pittendrigh, 1996.4.29, Feyereisen and Dunkov, 1995.11.2)
                                                  44D1-44D2
                                                  (determined by in situ hybridisation)
                                                  (Dunkov et al., 1996)
                                                  Experimentally Determined Recombination Data
                                                  Location

                                                  2-59

                                                  (FlyBase, 2016)

                                                  2-57.6

                                                  (Comeron et al., 2012)

                                                  2-

                                                  (Feyereisen and Dunkov, 1995.11.2)
                                                  Left of (cM)
                                                  Right of (cM)
                                                  Notes
                                                  Stocks and Reagents
                                                  Stocks (9)
                                                  Genomic Clones (17)
                                                   

                                                  Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                                                  cDNA Clones (57)
                                                   

                                                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                                                  cDNA clones, fully sequenced
                                                  BDGP DGC clones
                                                  Other clones
                                                  Drosophila Genomics Resource Center cDNA clones

                                                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                                                  cDNA Clones, End Sequenced (ESTs)
                                                  BDGP DGC clones
                                                  Other clones
                                                  RNAi and Array Information
                                                  Linkouts
                                                  DRSC - Results frm RNAi screens
                                                  Antibody Information
                                                  Laboratory Generated Antibodies
                                                   
                                                  Commercially Available Antibodies
                                                   
                                                  Cell Line Information
                                                  Publicly Available Cell Lines
                                                   
                                                    Other Stable Cell Lines
                                                     
                                                      Other Comments

                                                      Gene expression is increased in response to the presence of either one or two copies of Scer\GAL4hs.PB.

                                                      (Liu and Lehmann, 2008)

                                                      Transcriptionally downregulated after 2h of insulin stimulation in Kc167 cells. Contains fkh response elements (FHREs) in the genomic upstream or intronic sequences.

                                                      (Junger et al., 2003)

                                                      Identified molecularly using degenerate PCR primers designed from conserved regions of known insect P450 genes.

                                                      (Dunkov et al., 1996)

                                                      Cyp4e2 has been cloned and sequenced.

                                                      (Pittendrigh et al., 1996)

                                                      Overexpressed in the Raleigh DDT resistant strain. Cyp4e2 is inducible by phenobarbitol.

                                                      (Amichot et al., 1994)

                                                      The adenylate cyclase inactivator forskolin and its pharmacologically inactive derivative 1,9-dideoxyforskolin inhibit, in a dose-dependent fashion, the ecdysone 20-monooxygenase activity associated with wandering stage larvae.

                                                      (Keogh et al., 1992)
                                                      Relationship to Other Genes
                                                      Source for database merge of
                                                      Additional comments

                                                      The genes Cyp4e1 and Cyp4e2 share >70% identity and close proximity, and so may have been derived from a DNA-based tandem duplication.

                                                      (Langille and Clark, 2007)
                                                      Nomenclature History
                                                      Source for database identify of

                                                      Source for identity of: Cyp4e2 CG2060

                                                      (Heiman, 1999.11)
                                                      Nomenclature comments
                                                      Etymology
                                                      Synonyms and Secondary IDs (13)
                                                      Datasets (0)
                                                      Study focus (0)
                                                      Experimental Role
                                                      Project
                                                      Project Type
                                                      Title
                                                      Study result (0)
                                                      Result
                                                      Result Type
                                                      Title
                                                      External Crossreferences and Linkouts ( 52 )
                                                      Sequence Crossreferences
                                                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                                                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                                                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                                                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                                                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                                                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                                                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                                                      Other crossreferences
                                                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                                                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                                                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                                                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                                                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                                                      FlyMine - An integrated database for Drosophila genomics
                                                      InterPro - A database of protein families, domains and functional sites
                                                      KEGG Genes - Molecular building blocks of life in the genomic space.
                                                      MARRVEL_MODEL - MARRVEL (model organism gene)
                                                      Linkouts
                                                      BioGRID - A database of protein and genetic interactions.
                                                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                                                      DroID - A comprehensive database of gene and protein interactions.
                                                      DRSC - Results frm RNAi screens
                                                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                                                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                                                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                                                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                                                      Flygut - An atlas of the Drosophila adult midgut
                                                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                                                      MIST (protein-protein) - An integrated Molecular Interaction Database
                                                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                                                      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
                                                      References (107)