FlyBase Gene Report: Dmel\Cyp301a1

General Information

Symbol

Dmel\Cyp301a1

Species

D. melanogaster

Name

Cytochrome P450 301a1

Annotation Symbol

CG8587

Feature Type

protein_coding_gene

FlyBase ID

FBgn0033753

Gene Model Status

Current

Stock Availability

6 publicly available

Gene Summary

Cyp301a1 (Cyp301a1) encodes a member of the cytochrome P450 family, which have both mitochondrial and cytosolic roles in the detoxification of compounds. [Date last reviewed: 2018-10-11] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

49B4-49B5

Sequence location

2R:12,566,185..12,569,061 [+]

Recombination map

2-67

RefSeq locus

NT_033778 REGION:12566185..12569061

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (4 terms)

CV Term

Evidence

References

enables heme binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables iron ion binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables monooxygenase activity

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

Biological Process (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in tergite morphogenesis

inferred from mutant phenotype

(Sztal et al., 2012)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

CYTOCHROME P450 - MITO CLAN

Protein Family (UniProt)

Belongs to the cytochrome P450 family. (Q9V6D6)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Cyp301a1 (Cyp301a1) encodes a member of the cytochrome P450 family, which have both mitochondrial and cytosolic roles in the detoxification of compounds. [Date last reviewed: 2018-10-11]

Gene Group (FlyBase)

CYTOCHROME P450 - MITO CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The MITO clan includes D. melanogaster CYP12, 49, 301, 302, 314 and 315 family genes. Members are localized to mitochondria and at least some are linked to the ecdysteroid metabolism pathway. (Adapted from FBrf0248421.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp301a1 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9V6D6)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.49

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp301a1-RA

FBtr0087824

NM_136952

1940

553

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyp301a1-PA

FBpp0086937

62.8

553

8.71

Q9V6D6

NP_610796

AAF58492

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9V6D6

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp301a1 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyp301a1_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.46

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 2

organism

(Sztal et al., 2012, Chung et al., 2009)

embryonic stage 12 -- 16

embryonic/larval tracheal section

(Chung et al., 2011)

embryonic stage 12 -- 17

embryonic/larval hindgut

(Sztal et al., 2012)

embryonic stage 17

embryonic/larval epidermis

(Sztal et al., 2012)

larval stage

larval tracheal system

(Sztal et al., 2012)

third instar larval stage

embryonic/larval hindgut

(Sztal et al., 2012, Chung et al., 2009)

pupal stage -- adult stage

adult hindgut

(Sztal et al., 2012)

adult stage

adult integumentary system

(Sztal et al., 2012)

RT-PCR

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage -- adult stage

organism

(Sztal et al., 2012)

Additional Descriptive Data

Cyp301a1 is detected in all life stages by RT-PCR. Levels are high in 2nd instar larvae, decrease in third instar, and are absent in wandering third instar. Levels rise during pupal formation and again prior to eclosion. In addition to expression in embryonic hindgut and epidermis, expression was observed in pupal and adult hindgut, larval trachea, larval carcass, and adult integument.

(Sztal et al., 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp301a1 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp301a1

View exonic expression by tissue for Dmel\Cyp301a1

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36378/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033753

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033753

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8587

Flygut - An atlas of the Drosophila adult midgut

FBgn0033753

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cyp301a1

Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 4 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 6 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp301a1

Transgenic constructs containing regulatory region of Cyp301a1

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

partially lethal - majority live | recessive

Cyp301a1^f02301

viable

Cyp301a1^f02301

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Cyp301a1^GD13977

viable, with Scer\GAL4^Mef2.PR

Cyp301a1^GD13977

viable, with Scer\GAL4^pnr-MD237

Cyp301a1^GD13977

viable, with Scer\GAL4^tin.CΔ4

Cyp301a1^GD13977

Sterility

Allele

fertile

Cyp301a1^f02301

Other Phenotypes

Allele

abnormal body color, with Scer\GAL4^pnr-MD237

Cyp301a1^GD13977

visible, with Scer\GAL4^αTub84B.PL

Cyp301a1^RNAi.UAS

visible | recessive

Cyp301a1^f02301

Phenotype manifest in

Allele

abdominal tergite

Cyp301a1^f02301

adult cuticle

Cyp301a1^f02301

adult cuticle, with Scer\GAL4^αTub84B.PL

Cyp301a1^RNAi.UAS

mesonotum, with Scer\GAL4^pnr-MD237

Cyp301a1^GD13977

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (29)

Hsap\CYP24A1

8 of 14

Yes

7 of 14

7 of 14

7 of 14

4 of 14

Yes

Hsap\CYP11B1

3 of 14

Yes

Hsap\CYP11B2

3 of 14

Yes

Hsap\CYP26A1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (23)

Rnor\Cyp24a1

7 of 14

Yes

Rnor\Cyp27a1

7 of 14

Yes

Rnor\Cyp27b1

7 of 14

Yes

Rnor\Cyp11a1

3 of 14

Rnor\Cyp11b2

3 of 14

Yes

Rnor\Cyp11b3

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cyp26a1

1 of 14

Yes

Rnor\Cyp26b1

1 of 14

Yes

Rnor\LOC680316

1 of 14

Yes

Mus musculus (laboratory mouse) (24)

Mmus\Cyp24a1

8 of 14

Yes

Mmus\Cyp27b1

7 of 14

Mmus\Cyp11a1

6 of 14

Yes

Mmus\Cyp27a1

6 of 14

Mmus\Cyp11b1

4 of 14

Yes

Mmus\Cyp11b2

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Cyp26b1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (32)

Xtro\cyp24a1

7 of 13

Yes

6 of 13

6 of 13

6 of 13

5 of 13

5 of 13

5 of 13

4 of 13

Yes

Xtro\LOC100496967

4 of 13

Xtro\cyp26a1

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (26)

Drer\cyp24a1

7 of 14

Yes

Drer\cyp27a1.2

7 of 14

Yes

Drer\cyp27a1.4

7 of 14

Yes

Drer\cyp27a7

7 of 14

Yes

Drer\cyp27c1

7 of 14

Yes

Drer\si:ch211-113j14.1

7 of 14

Yes

Drer\si:dkey-91i10.3

7 of 14

Yes

Drer\zgc:136333

7 of 14

Yes

Drer\cyp11a2

5 of 14

Yes

Drer\cyp27b1

5 of 14

Drer\cyp11a1

4 of 14

Yes

Drer\cyp11c1

3 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\cyp26b1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (33)

Cele\cyp-44A1

9 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (65)

Agam\AgaP_AGAP006082

12 of 12

Yes

6 of 12

6 of 12

5 of 12

5 of 12

5 of 12

5 of 12

5 of 12

4 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (58)

Atha\AT2G12190

2 of 13

Yes

Atha\CYP82C2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (1)

Scer\DIT2

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyp301a1. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (56)

10 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

9 of 13

dib

7 of 13

shd

5 of 13

sad

3 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

CYP24A1; cytochrome P450 family 24 subfamily A member 1

model of infantile hypercalcemia 1

IEA

(FlyBase, 2019-)

CYP11A1; cytochrome P450 family 11 subfamily A member 1

model of congenital adrenal insufficiency

IEA

(FlyBase, 2019-)

CYP11B1; cytochrome P450 family 11 subfamily B member 1

model of glucocorticoid-remediable aldosteronism

IEA

(FlyBase, 2019-)

model of congenital adrenal hyperplasia

IEA

(FlyBase, 2019-)

CYP11B2; cytochrome P450 family 11 subfamily B member 2

model of corticosterone methyloxidase deficiency 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Cyp301a1^GD13977

exacerbates tauopathy

modeled by Hsap\MAPT^R406W.UAS

(Butzlaff et al., 2015)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYP24A1; cytochrome P450 family 24 subfamily A member 1

8 of 14

126065

HYPERCALCEMIA, INFANTILE, 1; HCINF1

infantile hypercalcemia 1

CYP27A1; cytochrome P450 family 27 subfamily A member 1

7 of 14

606530

CEREBROTENDINOUS XANTHOMATOSIS; CTX

cerebrotendinous xanthomatosis

CYP27B1; cytochrome P450 family 27 subfamily B member 1

7 of 14

609506

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

vitamin D-dependent rickets type 1A

CYP27C1; cytochrome P450 family 27 subfamily C member 1

7 of 14

620605

CYP11A1; cytochrome P450 family 11 subfamily A member 1

4 of 14

118485

ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE

congenital adrenal insufficiency

CYP11B1; cytochrome P450 family 11 subfamily B member 1

3 of 14

610613

CYP11B2; cytochrome P450 family 11 subfamily B member 2

3 of 14

124080

corticosterone methyloxidase deficiency 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0033753

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-67

Cytogenetic map

49B4-49B5

Sequence location

2R:12,566,185..12,569,061 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

49B4-49B5

Limits computationally determined from genome sequence between P{EP}CG8569^EP1182 and P{EP}Amph^EP2175&P{lacW}spt4^k05316

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

49B1-49B2

(Dunkov, 2000.6.29)

Experimentally Determined Recombination Data

Location

2-67

(FlyBase, 2016)

2-69.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (6)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

18537

w¹¹¹⁸; PBac{WH}Cyp301a1^f02301

91279

y¹ w^*; TI{CRIMIC.TG4.2}Cyp301a1^{CR01707-TG4.2}/SM6a

NIG-Fly

8587R-1

P{NIG.8587R}1

2RG-0042

y² VhaAC39-1^cho-1 v¹; P{U6-Cyp301a1.NIG.sgRNA}attP40/CyO

VDRC

v109771

P{KK104123}VIE-260B

v26989

w¹¹¹⁸; P{GD13977}v26989/CyO

Genomic Clones (15)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (8)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE71294

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0033753

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

64652

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0033753

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

301a1

(Nelson, 2001.2.5)

CG8587

(National Institute of Genetics Fly Stocks, 2022-, Butzlaff et al., 2015, Keleman et al., 2009.8.5)

Cyp301A1

(Sztal et al., 2012)

Cyp301a1

(Scanlan et al., 2020, Gene Disruption Project members, 2018-, Butzlaff et al., 2015, Najarro et al., 2015, Good et al., 2014, Japanese National Institute of Genetics, 2012.5.21, Nfonsam et al., 2012, Sztal et al., 2012, Chung et al., 2011, Niwa et al., 2011)

cutl

(Good et al., 2014)

Name Synonyms

Cyp301a1

Cytochrome P450 301a1

cytochrome P450

(Chung et al., 2009)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 31 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36378

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9V6D6

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9V6D6

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9V6D6

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0033753

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36378/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0033753

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0033753

FlyMine - An integrated database for Drosophila genomics

FBgn0033753

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8587

MARRVEL_MODEL - MARRVEL (model organism gene)

36378

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0033753

DroID - A comprehensive database of gene and protein interactions.

FBgn0033753

DRSC - Results frm RNAi screens

FBgn0033753

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Cyp301a1_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0033753

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0033753

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG8587

Flygut - An atlas of the Drosophila adult midgut

FBgn0033753

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC008302

References (52)

The following external sites may use different assemblies or annotations than FlyBase.

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