FlyBase Gene Report: Dmel\Cyp12d1-d

General Information

Symbol

Dmel\Cyp12d1-d

Species

D. melanogaster

Name

Cytochrome P450 12d1 distal

Annotation Symbol

CG33503

Feature Type

protein_coding_gene

FlyBase ID

FBgn0053503

Gene Model Status

Current

Stock Availability

2 publicly available

Gene Summary

Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

Cyp12d1, Cyp12d2

Key Links

Genomic Location

Cytogenetic map

47D4-47D4

Sequence location

2R:11,123,658..11,125,647 [-]

Recombination map

2-63

RefSeq locus

NT_033778 REGION:11123658..11125647

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (9 terms)

Molecular Function (5 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (5 terms)

CV Term

Evidence

References

enables 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity

inferred from sequence or structural similarity with UniProtKB:Q07973

(Gene Ontology Curators, 2002-)

enables heme binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables iron ion binding

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables monooxygenase activity

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR036396

(InterPro Project Members, 2004-)

enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972, InterPro:IPR036396

(InterPro Project Members, 2004-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in response to DDT

inferred from mutant phenotype

(Daborn et al., 2007)

involved_in response to insecticide

inferred from mutant phenotype

(Daborn et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in vitamin D catabolic process

inferred from sequence or structural similarity with UniProtKB:Q07973

(Gene Ontology Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

located_in mitochondrion

inferred from sequence or structural similarity with UniProtKB:Q9DBG1

(Gene Ontology Curators, 2002-)

Gene Group (FlyBase)

CYTOCHROME P450 - MITO CLAN

Protein Family (UniProt)

Belongs to the cytochrome P450 family. (Q7KR10)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
RHEA 24964:

Summaries

Gene Snapshot

Cyp12d1-d (Cyp12d1-d) encodes a protein involved in the response to the insecticide dichlorodiphenyltrichloroethane (DDT). [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

CYTOCHROME P450 - MITO CLAN -: Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The MITO clan includes D. melanogaster CYP12, 49, 301, 302, 314 and 315 family genes. Members are localized to mitochondria and at least some are linked to the ecdysteroid metabolism pathway. (Adapted from FBrf0248421.)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Cyp12d1-d for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q7KR10)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Cyp12d1-d and Cyp12d1-p derived from a tandem duplication of Cyp12d1 in the melanogaster group (FBrf0219004).

In most Drosophila melanogaster strains tested, there is a single Cyp12d1 gene instead of two tandemly duplicated copies (FBrf0219004).

Gene model reviewed during 5.48

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Cyp12d1-d-RA

FBtr0089418

NM_206090

1812

521

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Cyp12d1-d-PA

FBpp0088436

60.3

521

9.55

Q7KR10

NP_995812

AAG22287

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q7KR10

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cyp12d1-d using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 7 -- 12

embryonic/larval midgut primordium

(Chung et al., 2009)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

clypeo-labral primordium

(Fisher et al., 2012)

foregut primordium

(Fisher et al., 2012)

yolk nucleus

(Fisher et al., 2012)

embryonic head | restricted

(Chung et al., 2009)

third instar larval stage

embryonic/larval Malpighian tubule

(Chung et al., 2009)

gastric caecum

(Chung et al., 2009)

embryonic/larval fat body

(Chung et al., 2009)

oogenesis stage S9 -- S13 & adult stage | female

stretch follicle cell

(Peters et al., 2013)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Cyp12d1-d in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Cyp12d1-d

View exonic expression by tissue for Dmel\Cyp12d1-d

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053503

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768720/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053503

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053503

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053503

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33503

Flygut - An atlas of the Drosophila adult midgut

FBgn0053503

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Cyp12d1-d

Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 3 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Cyp12d1-d

Transgenic constructs containing regulatory region of Cyp12d1-d

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 9 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

chemical resistant, with Scer\GAL4^Cyp6g1.HR

Cyp12d1-d^UAS.cDa

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (33)

Hsap\CYP24A1

8 of 14

Yes

Hsap\CYP27A1

8 of 14

Yes

Hsap\CYP27B1

8 of 14

Yes

Hsap\CYP27C1

8 of 14

Yes

Hsap\CYP11A1

4 of 14

Yes

Hsap\CYP11B1

3 of 14

Yes

Hsap\CYP11B2

3 of 14

Yes

Hsap\CYP4Z1

2 of 14

Hsap\CYP46A1

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\CYP51A1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (24)

Rnor\Cyp27a1

8 of 14

Yes

Rnor\Cyp27b1

8 of 14

Yes

Rnor\Cyp24a1

7 of 14

Rnor\Cyp11a1

3 of 14

Rnor\Cyp11b2

3 of 14

Yes

Rnor\Cyp11b3

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\Cyp19a1

1 of 14

Rnor\Cyp46a1

1 of 14

Rnor\LOC680316

1 of 14

Yes

Mus musculus (laboratory mouse) (25)

Mmus\Cyp24a1

8 of 14

Yes

Mmus\Cyp27b1

8 of 14

Yes

Mmus\Cyp27a1

7 of 14

Mmus\Cyp11a1

6 of 14

Yes

Mmus\Cyp11b1

4 of 14

Yes

Mmus\Cyp11b2

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (43)

Xtro\cyp24a1

7 of 13

Yes

Xtro\cyp27b1

7 of 13

Yes

Xtro\il17d

7 of 13

Yes

Xtro\XB1001094

7 of 13

Yes

Xtro\LOC116407844

6 of 13

Yes

Xtro\cyp27a1.3

5 of 13

Xtro\XB984297

5 of 13

Xtro\cyp11a1

4 of 13

Yes

Xtro\LOC100496967

4 of 13

Xtro\cyp27c1

2 of 13

Xtro\cyp46a1.3

2 of 13

Yes

Xtro\LOC100498621

2 of 13

Yes

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\cyp27a1

1 of 13

Xtro\cyp46a1.1

1 of 13

Yes

Xtro\cyp46a1.2

1 of 13

Yes

Xtro\ercc3

1 of 13

Xtro\LOC100145328

1 of 13

Yes

Xtro\LOC100488078

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (27)

Drer\cyp27a1.2

7 of 14

Yes

Drer\cyp27a1.4

7 of 14

Yes

Drer\cyp27a7

7 of 14

Yes

Drer\cyp27c1

7 of 14

Yes

Drer\si:ch211-113j14.1

7 of 14

Yes

Drer\si:dkey-91i10.3

7 of 14

Yes

Drer\zgc:136333

7 of 14

Yes

Drer\cyp24a1

6 of 14

Drer\cyp11a2

5 of 14

Yes

Drer\cyp27b1

5 of 14

Drer\cyp11a1

4 of 14

Yes

Drer\cyp11c1

3 of 14

Yes

Drer\cyp46a1.2

2 of 14

Yes

Drer\cyp46a1.4

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\tbxas1

1 of 14

Drer\zgc:123299

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (36)

Cele\cyp-44A1

10 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Anopheles gambiae (African malaria mosquito) (67)

Agam\AgaP_AGAP008018

8 of 12

Yes

Agam\AgaP_AGAP008019

8 of 12

Yes

Agam\AgaP_AGAP008022

8 of 12

Yes

7 of 12

6 of 12

5 of 12

5 of 12

5 of 12

4 of 12

4 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (111)

Atha\BAS1

2 of 13

Yes

Atha\CYP88A3

2 of 13

Yes

Atha\CYP708A2

2 of 13

Yes

Atha\CYP709B3

2 of 13

Yes

Atha\KAO2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\BR6OX1

1 of 13

Yes

Atha\BR6OX2

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\GA3

1 of 13

Yes

Atha\LUT1

1 of 13

Atha\ROT3

1 of 13

Yes

Atha\TT7

1 of 13

Atha\UNE9

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\DIT2

1 of 13

Yes

Scer\ERG11

1 of 13

Yes

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Cyp12d1-d. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (57)

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

10 of 13

9 of 13

9 of 13

dib

6 of 13

Cyp313a1

4 of 13

Cyp313a4

4 of 13

shd

4 of 13

Cyp313a2

3 of 13

Cyp313a3

3 of 13

Cyp313a5

3 of 13

sad

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 7 )

Human Ortholog

Disease

Evidence

References

CYP24A1; cytochrome P450 family 24 subfamily A member 1

model of infantile hypercalcemia 1

IEA

(FlyBase, 2019-)

CYP27B1; cytochrome P450 family 27 subfamily B member 1

model of vitamin D-dependent rickets type 1A

IEA

(FlyBase, 2019-)

CYP27A1; cytochrome P450 family 27 subfamily A member 1

model of cerebrotendinous xanthomatosis

IEA

(FlyBase, 2019-)

CYP11A1; cytochrome P450 family 11 subfamily A member 1

model of congenital adrenal insufficiency

IEA

(FlyBase, 2019-)

CYP11B1; cytochrome P450 family 11 subfamily B member 1

model of glucocorticoid-remediable aldosteronism

IEA

(FlyBase, 2019-)

model of congenital adrenal hyperplasia

IEA

(FlyBase, 2019-)

CYP11B2; cytochrome P450 family 11 subfamily B member 2

model of corticosterone methyloxidase deficiency 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

CYP24A1; cytochrome P450 family 24 subfamily A member 1

8 of 14

126065

HYPERCALCEMIA, INFANTILE, 1; HCINF1

infantile hypercalcemia 1

CYP27A1; cytochrome P450 family 27 subfamily A member 1

8 of 14

606530

CEREBROTENDINOUS XANTHOMATOSIS; CTX

cerebrotendinous xanthomatosis

CYP27B1; cytochrome P450 family 27 subfamily B member 1

8 of 14

609506

VITAMIN D HYDROXYLATION-DEFICIENT RICKETS, TYPE 1A; VDDR1A

vitamin D-dependent rickets type 1A

CYP27C1; cytochrome P450 family 27 subfamily C member 1

8 of 14

620605

CYP11A1; cytochrome P450 family 11 subfamily A member 1

4 of 14

118485

ADRENAL INSUFFICIENCY, CONGENITAL, WITH 46,XY SEX REVERSAL, PARTIAL OR COMPLETE

congenital adrenal insufficiency

CYP11B1; cytochrome P450 family 11 subfamily B member 1

3 of 14

610613

CYP11B2; cytochrome P450 family 11 subfamily B member 2

3 of 14

124080

corticosterone methyloxidase deficiency 1

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0053503

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-63

Cytogenetic map

47D4-47D4

Sequence location

2R:11,123,658..11,125,647 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

47D4-47D4

Limits computationally determined from genome sequence between P{lacW}l(2)k15826^k15826&P{EP}EP471 and P{EP}shn^EP2359&P{EP}shn^EP644

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

47E-47E

(Dunkov, 2000.6.29)

Experimentally Determined Recombination Data

Location

2-63

(FlyBase, 2016)

2-63.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (2)

Aberrations including deletions of this gene Aberrations including duplications of this gene

NIG-Fly

HMJ21510

y¹ v¹; P{TRiP.HMJ21510}attP40/CyO

VDRC

v109248

P{KK116216}VIE-260B

Genomic Clones (12)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (19)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0053503

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0053503

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Festucci-Buselli et al., 2005)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Two "Cyp12d1" genes are present in a tandem duplication at 47D; Cyp12d1-p (proximal) and Cyp12d1-d (distal). The release 3.2 annotations for these two genes are CG30489 (Cyp12d1-p) and CG33503 (Cyp12d1-d). Annotation CG30489 was labelled "CG18240" in release 2 of the genome annotation and "CG30489" in releases 3.0 and 3.1. Annotation CG33503 was labelled "CG18239" in release 2 of the genome annotation and "CG18240" in releases 3.0 and 3.1.

(FlyBase Genome Annotators, 2004)

FlyBase curator comment: Figure 4 of FBrf0123240 lists "CYP12A2" associated with clone GM06292 (NCBI AA802777). That sequence is a ~100% BLAST hit to Cyp12d1-p and Cyp12d1-d, and that clone is linked to those two genes in FlyBase. On that basis, the 'Cyp12a2' (FBgn0040476) gene report has been obsoleted and 'CYP12A2' added as a synonym to Cyp12d1-p and Cyp12d1-d.

(White et al., 1999)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (19)

Reported As

Symbol Synonym

12D1

(Tijet et al., 2001)

12d1

(Kasai and Tomita, 2003)

CG18239

(Apidianakis et al., 2005, Bochdanovits and de Jong, 2004)

CG18240

(Jensen et al., 2006)

CG33503

(National Institute of Genetics Fly Stocks, 2023-, Çiçek et al., 2016, Gallach et al., 2010, Mosallanejad et al., 2010, Keleman et al., 2009.8.5, Le Goff et al., 2006)

CT26082

(Dunkov, 2000.6.29)

CYP12A2

(White et al., 1999)

CYP12D1

(Li et al., 2015, Jones et al., 2010, Chen and Li, 2007, Degtyarenko, 2000.9.19, Dunkov, 2000.10.12)

CYP12d1-d

(Coelho et al., 2015)

Cyp 12d1

(Jensen et al., 2006)

Cyp12d

(Good et al., 2014)

Cyp12d1-d

(Haas et al., 2025, Etges, 2019, Zhang and Zhang, 2019, Hudry et al., 2016, Lamiable et al., 2016, Bartok et al., 2015, Najarro et al., 2015, Van Bortle et al., 2015, Zhao et al., 2015, Schrider et al., 2013, McDonnell et al., 2012, Chen et al., 2011, Ayroles et al., 2009, Telonis-Scott et al., 2009, Curtis et al., 2007, Zraly et al., 2006)

Cyp12d2

(Pedra et al., 2004, Le Goff et al., 2003)

cyp12d1

(Sharma et al., 2018)

cyp12d1-d

(Bost et al., 2018)

Name Synonyms

Cyp12d1-d

Cytochrome P450 12d1 distal

Cytochrome P450-12d1

(Peters et al., 2013)

cytochrome P450

(Chung et al., 2009)

Secondary FlyBase IDs

FBgn0033576
FBgn0033577
FBgn0041339

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

2768720

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q7KR10

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q7KR10

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q7KR10

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0053503

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

2768720/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0053503

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0053503

FlyMine - An integrated database for Drosophila genomics

FBgn0053503

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG33503

MARRVEL_MODEL - MARRVEL (model organism gene)

2768720

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0053503

DroID - A comprehensive database of gene and protein interactions.

FBgn0053503

DRSC - Results frm RNAi screens

FBgn0053503

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0053503

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0053503

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG33503

Flygut - An atlas of the Drosophila adult midgut

FBgn0053503

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC016365

References (94)

The following external sites may use different assemblies or annotations than FlyBase.

NA

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