Subject: mitochondrial P450s in Drosophila
comments: CYP12A4, CYP12A5, CYP12B2, CYP12C1, CYP12D1, CYP12E1, CYP301A1
and CYP302A1 have more similarity to Musca domestica CYP12A1,
which is a mitochondrial protein, and to mammalian mitochondrial
P450s than to microsomal P450s. Therefore for these P450s
'mitochondrial' is more plausible cellular location
Source of information:
1) Rene Feyereisen (personal communication)
2) BLAST searches of the above proteins
3) Guzov, V.M., Unnithan, G.C., Chernogolov, A.A. and Feyereisen, R.
(1998) CYP12A1, a mitochondrial cytochrome P450 from the house fly.
Arch. Biochem. Biophys. 359, 231-240.