FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene Group: CYTOCHROME P450 - MITO CLAN
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General Information
Name
CYTOCHROME P450 - MITO CLAN
Species
D. melanogaster
Symbol
CYP450-MITO
FlyBase ID
FBgg0001697
Date last reviewed
2021-03-11
Number of members
12
Description
Description
Cytochrome P450, or CYP genes, constitute one of the largest families of genes, with representatives in virtually all living organisms. P450 enzymes are heme-thiolate proteins best known for their monooxygenase role, catalyzing the transfer of one atom of molecular oxygen to a substrate and reducing the other to water. The MITO clan includes D. melanogaster CYP12, 49, 301, 302, 314 and 315 family genes. Members are localized to mitochondria and at least some are linked to the ecdysteroid metabolism pathway. (Adapted from FBrf0248421.)
Notes on Group

Three cytochrome P450 MITO clan members, dib (Cyp302a1), shd (Cyp314a1) and sad (Cyp315a1), are known as 'Halloween genes' whose products are involved in the ecdysteroid biosynthetic pathway (FBrf0201926).

Source Material
The CYTOCHROME P450 - MITO CLAN Gene Group has been compiled using the following publication(s): Dermauw et al., 2020, Feyereisen, 2012, Feyereisen, 2006, and Tijet et al., 2001 .
Key Gene Ontology (GO) terms
Molecular Function
monooxygenase activity
Biological Process
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
CYTOCHROME P450
Members (12)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
CYP450-MITO
CYTOCHROME P450 - MITO CLAN
Secondary FlyBase ID(s)
References (5)