Gene Group: M100 METALLOENDOPEPTIDASES

General Information

Name

M100 METALLOENDOPEPTIDASES

Species

D. melanogaster

Symbol

M100

FlyBase ID

FBgg0001742

Date last reviewed

2022-07-05

Number of members

Description

M100 metalloendopeptidases belong to MEROPS family M100. The founding member is human SPARTAN, a conserved DNA-dependent metalloprotease essential for resolving DNA-protein cross-links, which thus plays a key role in maintaining genomic integrity. (Adapted from PMID: 28615282.)

Notes on Group

The single member of the M100 METALLOENDOPEPTIDASES gene group, mh, is classed as a inactive non-peptidase homolog by MEROPS, but FBrf0226393 and FBrf0236260 suggest that mh encodes an active peptidase.

Source Material

The M100 METALLOENDOPEPTIDASES Gene Group has been compiled using the following publication(s): Tang et al., 2017 and Delabaere et al., 2014 .

Key Gene Ontology (GO) terms

Molecular Function

metalloendopeptidase activity

Biological Process

protein-DNA covalent cross-linking repair

proteolysis

Cellular Component

Enzymatic activity

Enzyme name (EC)

3.4.24.-