Gene Group: UBIQUITIN-LIKE PROTEIN PEPTIDASES

General Information

Name

UBIQUITIN-LIKE PROTEIN PEPTIDASES

Species

D. melanogaster

Symbol

ULPP

FlyBase ID

FBgg0001779

Date last reviewed

2022-02-11

Number of members

Description

Ubiquitin-like protein peptidases catalyse the hydrolysis of the peptide or isopeptide bond between ubiquitin or a ubiquitin-like protein (e.g. ATG8, NEDD8, SUMO, UFM1) and the larger protein to which it has been conjugated. They also cleave the bonds within chains of ubiquitin(-like) proteins. As such, they reverse the modification of proteins by a single ubiquitin(-like) protein, and remodel polyubiquitin(-like) chains on target proteins. The majority of ubiquitin-like protein proteases are cysteine-type peptidases, though some are metallopeptidases. (Adapted from PMID:19489724.)

Notes on Group

Source Material

The UBIQUITIN-LIKE PROTEIN PEPTIDASES Gene Group has been compiled using the following publication(s): Erven et al., 2022, Páhi et al., 2022, Badmos et al., 2021, Louis et al., 2015, Engel et al., 2014, Clague et al., 2013, Berdnik et al., 2012, Tsou et al., 2012, Zhang et al., 2012, Chan et al., 2008, Wei et al., 2008, Kang et al., 2007, Doronkin et al., 2003, Cope et al., 2002, and Rawlings and Barrett, 1996- .

Key Gene Ontology (GO) terms

Molecular Function

ubiquitin-like protein peptidase activity

Biological Process

protein modification by small protein removal

Cellular Component

Related Gene Groups

Parent group(s)

PEPTIDASES

Component group(s)

ATG8 PROTEASES

DENEDDYLASES