Voltage-gated Ca[2+] channels (CACN) allow the influx of extracellular Ca[2+] in response to plasma membrane depolarization. CACNs are hetero-oligomeric assemblies of a voltage-gated, pore-forming α1 subunit and accessory subunits that modulate channel activity. (Adapted from
FBrf0218524 and
PMID:21746798).