FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Complex: TIM22 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX
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General Information
Name
TIM22 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX
Species
D. melanogaster
Symbol
TIMM22
FlyBase ID
FBgg0001905
Date last reviewed
2026-02-04
Number of members
6
Description
Description
The TIM22 mitochondrial import inner membrane insertion complex mediates the import and insertion of multipass transmembrane proteins into the mitochondrial inner membrane. The channel is formed by the Tim22 subunit. Tim9-10 form a peripheral membrane chaperone subcomplex in the mitochondrial intermembrane space. (Adapted from PMID:32901109.)
Notes on Group

The cryoEM structure of the human TIM22 complex (PMID:32901109) showed that the complex contained one TIMM22, one TIMM29 and one AGK subunit, plus two hexameric chaperone complexes: Tim9/10a ( 3:3 ) and Tim9/10a/10b ( 2:3:1 ). In D.mel, Tim10 is the ortholog of human TIMM10; Tim9a of TIMM9 and Tim9b of TIMM10b. The two hexameric chaperone complexes have also been curated as separate mitochondrial intermembrane space chaperone complexes.

Source Material
The TIM22 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX Gene Group has been compiled using the following publication(s): Attrill, 2024.1.5 .
Key Gene Ontology (GO) terms
Molecular Function
membrane insertase activity
Biological Process
protein insertion into mitochondrial inner membrane
Cellular Component
TIM22 mitochondrial import inner membrane insertion complex
Related Gene Groups
Parent group(s)
MITOCHONDRIAL PROTEIN TRANSPORT SYSTEM
Members (6)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
TIMM22
TIM22 TRANSLOCASE OF INNER MITOCHONDRIAL MEMBRANE COMPLEX
Secondary FlyBase ID(s)
References (2)