FB2026_02 , released June 18, 2026
Complex: TRNA-GUANINE TRANSGLYCOSYLASE COMPLEX
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General Information
Name
TRNA-GUANINE TRANSGLYCOSYLASE COMPLEX
Species
D. melanogaster
Symbol
TGTC
FlyBase ID
FBgg0002008
Date last reviewed
2024-08-07
Number of members
2
Description
Description
The tRNA-guanine transglycosylase complex catalyzes the base-exchange of a guanine residue with queuine at the wobble position of the anticodon of tRNAs. The eukaryotic tRNA-guanine transglycosylase exists as a heterodimer of a catalytic subunit (QTRT1 in humans) and an accessory subunit (QTRT2 in humans). (Adapted from PMID:20354154.)
Notes on Group
Source Material
Key Gene Ontology (GO) terms
Molecular Function
tRNA-guanosine(34) queuine transglycosylase activity
Biological Process
tRNA wobble base modification
Cellular Component
tRNA-guanine transglycosylase complex
Enzymatic activity
Enzyme name (EC)
tRNA-guanosine(34) queuine transglycosylase (2.4.2.64)
Related Gene Groups
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
TGTC
queuine tRNA-ribosyltransferase
QTRT
TRNA-GUANINE TRANSGLYCOSYLASE COMPLEX
Secondary FlyBase ID(s)
References (2)