Complex: INTEGRATOR-PP2A COMPLEX

General Information

Name

INTEGRATOR-PP2A COMPLEX

Species

D. melanogaster

Symbol

INTAC

FlyBase ID

FBgg0002031

Date last reviewed

2026-01-09

Number of members

Description

The Integrator-PP2A complex (INTAC) is a complex formed between the endonucleolytic integrator complex and a serine/threonine-protein phosphatase 2A (PP2A) module. The PP2A module is formed from a PP2A-A scaffold subunit and a PP2A-C catalytic subunit, but lacks the PP2A-B regulatory subunit characteristic of canonical PP2A complexes. INTAC inhibits promoter-proximal pause release of RNA polymerase II (Pol II) by the dephosphorylation of a number of targets including the C-terminal domain of Pol II. (Adapted from PMID:36180603.)

Notes on Group

The human ortholog of Sem1 has been characterised as being an integral component of the INTEGRATOR-PP2A COMPLEX. Sem1 has not been detected in interaction studies with the Drosophila complex (FBrf0263781 and FBrf0260214) and so has not been included. However, as stated in FBrf0263781 this "79-amino acid protein, is unlikely to have been recoverable in our mass spectrometry experiments".

Source Material

The INTEGRATOR-PP2A COMPLEX Gene Group has been compiled using the following publication(s): Lin et al., 2024 .

Key Gene Ontology (GO) terms

Molecular Function

RNA endonuclease activity

protein serine/threonine phosphatase activity

Biological Process

negative regulation of transcription elongation by RNA polymerase II

Cellular Component

nucleus

Enzymatic activity

Enzyme name (EC)