Pathway: HEPARAN SULFATE PROTEOGLYCAN CATABOLISM

General Information

Name

HEPARAN SULFATE PROTEOGLYCAN CATABOLISM

Species

D. melanogaster

Symbol

GAHSC

FlyBase ID

FBgg0002064

Date last reviewed

2024-12-18

Number of members

Description

Heparan sulfate proteoglycans (HSPGs) are glycoconjugates that consist of a core protein linked to one or more linear heparan sulfate (HS) chains. The chains are composed of alternating N-acetyl-D-glucosamine and glucuronic acid or iduronic acid that can be variably N- and O-sulfated. The degradation of HSPGs occurs in the lysosome. The HS chain is initially fragmented into oligosaccharides by an endo-glucuronidase. These oligosaccharides are then degraded sequentially from the nonreducing end by exo-type glycosidases and sulfatases to release the monosaccharide units. (Adapted from PMID:28741461.)

Notes

In D. melanogaster, the enzyme(s) involved in either the cleavage of heparan sulfate into oligosaccharides or the removal of the 3-O sulfate group from N-sulfoglucosamine are not known. CG15117 is a paralog of βGlu and is predominantly expressed in the male accessory gland. Although it has glucuronidase activity, it is not clear if it is involved in heparan sulfate proteoglycan catabolism, therefore CG15117 is not included in the gene list. Sulf1 is a paralog of CG18278 that extracellularly removes 6-O-sulfate groups from heparan sulfate. As it is not involved in heparan sulfate proteoglycan catabolism, Sulf1 is not included in the gene list.

Source Material

The HEPARAN SULFATE PROTEOGLYCAN CATABOLISM Gene Group has been compiled using the following publication(s): Hewson et al., 2024, De Filippis et al., 2021, Rigon et al., 2020, Bar et al., 2018, and Webber et al., 2018 .

Key Gene Ontology (GO) terms

Biological Process

heparan sulfate proteoglycan catabolic process

Cellular Component

lysosome

Related Gene Groups

Parent group(s)

GLYCOCONJUGATE METABOLISM

GO Causal Activity Model (GO-CAM)

Members (7)

For all members: