Pathway: GLYCOCONJUGATE METABOLISM

General Information

Name

GLYCOCONJUGATE METABOLISM

Species

D. melanogaster

Symbol

GLYCJM

FlyBase ID

FBgg0002137

Date last reviewed

2025-06-10

Number of members

137

Description

Glycoconjugates are proteins, lipids and RNAs that are covalently modified with one or more sugar units, which are known as glycans. Glycoconjugate metabolism covers the biosynthesis and the degradation of the attached glycan. Synthesis occurs mainly in the Golgi apparatus and the endoplasmic reticulum using nucleotide-sugar precursors, with sugars added sequentially to form linear or branched glycans. Glycan degradation occurs primarily in the lysosomes. Glycan modifications regulate glycoconjugate functions, including protein folding, signalling, adhesion and trafficking. (Adapted from FBrf0206870.)

Notes

Source Material

The GLYCOCONJUGATE METABOLISM Gene Group has been compiled using the following publication(s): Hewson et al., 2024, Dalton et al., 2022, Brandwine et al., 2021, De Filippis et al., 2021, Eisenhaber et al., 2021, Marygold, 2020.2.14, Rigon et al., 2020, Pandey et al., 2019, Zhang and Ten Hagen, 2019, Bar et al., 2018, Itoh et al., 2018, Pandey et al., 2018, Webber et al., 2018, Varshney and Stanley, 2017, Akan et al., 2016, Yamamoto-Hino et al., 2015, Rosenbaum et al., 2014, Satoh et al., 2013, Bunt et al., 2011, Kohyama-Koganeya et al., 2011, Johswich et al., 2009, Chen et al., 2007, Luo et al., 2006, Ichimiya et al., 2004, Kim et al., 2003, and Ten Hagen et al., 2003 .

Key Gene Ontology (GO) terms

Biological Process

glycoprotein metabolic process

glycolipid metabolic process

glycoRNA biosynthetic process

Cellular Component

Related Gene Groups

Component group(s)

CHONDROITIN SULFATE PROTEOGLYCAN CATABOLISM

DOLICHYL PHOSPHATE BIOSYNTHESIS

DOLICHYL-PHOSPHATE MANNOSE BIOSYNTHESIS

GLUCOSYLCERAMIDE BIOSYNTHESIS