FB2026_03 , released September 17, 2026
Pathway: PYRUVATE DECARBOXYLATION TO ACETYL-COA
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General Information
Name
PYRUVATE DECARBOXYLATION TO ACETYL-COA
Species
D. melanogaster
Symbol
PYRCOA
FlyBase ID
FBgg0002113
Date last reviewed
2025-05-20
Number of members
10
Description
Description
In this pathway, pyruvate generated by glycolysis enters the mitochondrion through the mitochondrial pyruvate carrier where it undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex into acetyl-CoA. Concomitantly, the complex releases CO2 and reduces NAD(+) to NADH. The acetyl-CoA subsequently enters the tricarboxylic acid (TCA) cycle. (Adapted from PMID:36581208 and PMID:19081061.)
Notes

Pdha2 is a paralog of Pdha1 and is specifically expressed in testis. As there is no functional information, Pdha2 is not included in the gene list. Mpc2c is a paralog of Mpc2a and Mpc2b and is specifically expressed in testis. As there is no functional information, Mpc2c is not included in the gene list.

Source Material
The PYRUVATE DECARBOXYLATION TO ACETYL-COA Gene Group has been compiled using the following publication(s): Marygold, 2024 and Wisidagama and Thummel, 2019 .
Key Gene Ontology (GO) terms
Biological Process
pyruvate decarboxylation to acetyl-CoA
Cellular Component
mitochondrion
Related Gene Groups
Parent group(s)
ENERGY METABOLISM
Other related group(s)
GLYCOLYSIS
TRICARBOXYLIC ACID (TCA) CYCLE
GO Causal Activity Model (GO-CAM)
Members (10)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Note: The Drosophila pathways shown at external resources are computed and may therefore differ from the manually curated and verified pathway shown above.
67e5e74400002207
Synonyms and Secondary IDs
Synonym(s)
PYRCOA
PYRUVATE DECARBOXYLATION TO ACETYL-COA
Secondary FlyBase ID(s)
References (4)