FB2026_02 , released June 18, 2026
Complex: CYCLIN K-CDK12 COMPLEX
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General Information
Name
CYCLIN K-CDK12 COMPLEX
Species
D. melanogaster
Symbol
CLNK-C12
FlyBase ID
FBgg0002118
Date last reviewed
2025-05-28
Number of members
2
Description
Description
The Cyclin K-CDK12 complex is involved in regulation of different transcription phases. It phosphorylates the C-terminal domain (CTD) of RNA polymerase II (CPX-2625).
Notes on Group

The Cyclin K-CDK12 complex was sourced from Complex Portal, curated by EMBL-EBI.

Source Material
The CYCLIN K-CDK12 COMPLEX Gene Group has been compiled using the following publication(s): Bartkowiak et al., 2010 .
Key Gene Ontology (GO) terms
Molecular Function
RNA polymerase II CTD heptapeptide repeat kinase activity
cyclin-dependent protein serine/threonine kinase activity
Biological Process
positive regulation of transcription elongation by RNA polymerase II
Cellular Component
cyclin K-CDK12 complex
Enzymatic activity
Enzyme name (EC)
cyclin-dependent kinase (2.7.11.22)
[RNA-polymerase]-subunit kinase (2.7.11.23)
Related Gene Groups
Members (2)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
CLNK-C12
CYCLIN K-CDK12 COMPLEX
Secondary FlyBase ID(s)
References (2)