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FB2026_01
,
released March 12, 2026
s36
Please see the JBrowse view of Dmel\Cp36 for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.45
1.2 (northern blot)
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Cp36 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: minus midline cells
The six major chorion bands are dramatically reduced in follicles of Mcm6K1214, mus101K451 and fs(1)A1059K1 mutants. No reduction of major chorion bands is seen in swa6 although some affects are seen in higher molecular weight components.
JBrowse - Visual display of RNA-Seq signals
View Dmel\Cp36 in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
In a sample of 79 genes with multiple introns, 33 showed significant heterogeneity in G+C content among introns of the same gene and significant positive correspondence between the intron and the third codon position G+C content within genes. These results are consistent with selection adding against preferred codons at the start of genes.
mus101K451, Mcm6K1214 and fs(1)A1059K1 mutants interfere with the amplification of the major chorion genes Cp15, Cp16, Cp18, Cp19, Cp36 and Cp38.
Approximately 1,000 daltons cleaved from primary translation product to yield mature protein.
Cp36 encodes s36-1, a 36,000-dalton chorion protein. Synthesis is primarily during stages 12 and 13 and during stages 11 and 12.
The 'dec2[1]' mutant allele had previously been assumed to be a strong hypomorphic mutation of the Cp36 gene encoding the s36 protein. However sequencing shows that 1. the 'dec2[1]' mutant chromosome contains a deletion that removes part of the CG33223 annotation, and 2. cDNA sequences of the transcripts encoded by the Cp36 gene are identical in Oregon-R and dec2[1] mutant females and are identical to the annotated transcript of the release 6.56 Cp36 gene annotation in FlyBase. In addition, immunochemical analysis indicates that the s36 protein encoded by the Cp36 gene is produced in dec2[1] mutant females (and there is no significant difference in the level of protein produced compared to Oregon-R), but that while the s36 protein forms insoluble aggregates in protein lysates of eggs of Oregon-R females, in eggs laid by dec2[1] mutant females the s36 protein is in the soluble fraction and is not detected in the eggshell. Thus the dec2[1] mutation does not appear to directly affect the Cp36 gene, but instead appears to be a mutation of CG33223, which may be involved in regulating (either directly or indirectly) the secretion of the s36 protein from follicle cells into the eggshell in the wild-type.
Source for identity of: Cp36 CG1478