FlyBase Gene Report: Dmel\M(3)69E

General Information

Symbol

Dmel\M(3)69E

Species

D. melanogaster

Name

Minute (3) 69E

Annotation Symbol

Feature Type

gene

FlyBase ID

FBgn0002616

Gene Model Status

Unannotated

Stock Availability

1 publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

M(3)h

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

M(3)69E

Moderate alleles have good viability and fertility; puparium formation delayed two days (Dunn and Mossige, 1937, Hereditas 23: 70-90; Ferrus, 1975, Genetics 79: 589-99). Extreme alleles have low viability, flimsy or waxy wings with plexus effects along vein L2 and at posterior crossvein; eyes may be small and rough.

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\M(3)69E using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\M(3)69E in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\M(3)69E

View exonic expression by tissue for Dmel\M(3)69E

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of M(3)69E

Transgenic constructs containing regulatory region of M(3)69E

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene not disrupted in

Df(3L)ED4486

(Marygold et al., 2007)

Gene disrupted in

Df(3L)VW1

(Ashburner et al., 1981)

Gene duplicated in

Dp(3;3)M67C⁺3

(del Prado and Ripoll, 1983)

Dp(3;3)M67C⁺5

(del Prado and Ripoll, 1983)

Gene not duplicated in

Dp(3;3)M67C⁺1

(del Prado and Ripoll, 1983)

Dp(3;3)M67C⁺4

(del Prado and Ripoll, 1983)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

abnormal developmental rate | dominant

M(3)69E⁵

abnormal developmental rate | dominant | larval stage

M(3)69E¹

abnormal eye color

M(3)69E²

Minute

M(3)69E⁵

Minute | dominant

visible | dominant

Phenotype manifest in

Allele

eye

macrochaeta

pigment cell

M(3)69E²

posterior crossvein

M(3)69E³

wing

wing vein L2

M(3)69E³

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:M(3)69E. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

M(3)69E

(Schultz, 1929)

run

enhanceable

M(3)69E

(Duffy et al., 1996)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0002616

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-[39]

Cytogenetic map

69E2-70A8

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

69E2-70A8

Left limit from inclusion within Df(3L)VW1 (FBrf0036112) Right limit from inclusion within Dp(3;3)M67C⁺3 (FBrf0039408)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-40.4

(Dunn and Mossige, 1937, Schultz, 1929)

3-[39]

Left of (cM)

(Plough and Ives, 1934)

Right of (cM)

Notes

Stocks and Reagents

Stocks (1)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Kyoto

105970

M(3)69E⁵/In(3L)P, Me¹

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

One of a class of genes (see MIN record) that when present in one, rather than two, copies, produce a characteristic phenotype consisting of short slender bristles and delayed development. Moderate alleles have good viability and fertility; puparium formation delayed two days (Dunn and Mossige, 1937; Ferrus, 1975). Extreme alleles have low viability, flimsy or waxy wings with plexus effects along vein L2 and at posterior crossvein; eyes may be small and rough.

Relationship to Other Genes

Source for database merge of

Additional comments

"RpS4" likely corresponds to "M(3)69E".

(Marygold et al., 2007)

It is not possible to say whether "M(3)69E" corresponds to "RpS12" or "RpS4", or whether the genetically-defined "M(3)69E" locus is a composite of both ribosomal protein genes.

(Deal and Cook, 2002.1.22)

M(3)69E⁴ and M(3)69E⁵ both lethal in trans heterozygotes with M(3)69E¹, but see M(3)66A; allelism of M(3)69E² and M(3)69E³ inferred from genetic map positions. Df(3L)M69E considered an allele in Lindsley and Grell (1968).

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

M(3)33d

M(3)33j

M(3)6

M(3)69E

(Marygold et al., 2007)

M(3)h

(Kongsuwan et al., 1985, Ashburner et al., 1981, Lindsley et al., 1972)

M(3)h^y

(del Prado and Ripoll, 1983)

M(3)v

M(3)y

M(3L)h

(Ferrus, 1975)

M^33d30

(Plough and Ives, 1934)

(Dunn and Mossige, 1937)

Name Synonyms

Minute (3) 69E

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 1 )

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0002616

References (18)

NA

Report Sections