FlyBase Gene Report: Dmel\costakink

General Information

Symbol

Dmel\costakink

Species

D. melanogaster

Name

costakink

Annotation Symbol

Feature Type

gene

FlyBase ID

FBgn0005399

Gene Model Status

Unannotated

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Red Book
Interactive Fly

Also Known As

l(1)BP4, l(1)10Aa, csk

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Phenotypic Description (Red Book; Lindsley and Zimm 1992)

csk: costakink

Most alleles are lethal; originally described on basis of a single surviving semilethal allele which displayed smaller eyes, with wings slightly reduced in size and abnormally held, with the costal vein frequently kinked near L2. Not fully penetrant; male viability and fertility good; female fertility reduced to about 50% wild type. Survivors of other semilethal or nearly lethal alleles display similar phenotype (Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khudyakov, and Belyaeva, 1987, Biol. Zentralbl. 106: 699-720). Lethal allele csk33, functions in homozygous germ-line clones, but has no maternal effect (Perrimon, Engstrom, and Mahowald, 1989, Genetics 121: 333-52). Fate maps, as a bilateral domineering mutant, to a broad region of the neurogenic ectoderm posterior to the metathoracic ganglion; in addition a nonautonomous focus in the wing disc gives rise to crumpled turned up wings (Bgatov, Zharkikh, and Zhimulev, 1984, Mol. Gen. Genet. 196: 110-16).

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Transcript Data

Annotated Transcripts

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Polypeptides with Identical Sequences

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\costakink using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

NA

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\costakink in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\costakink

View exonic expression by tissue for Dmel\costakink

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 42 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of costakink

Transgenic constructs containing regulatory region of costakink

Aberrations (Deficiencies and Duplications) ( 39 )

Inferred from experimentation ( 39 )

Gene disrupted in

Df(1)203C10

(Kozlova et al., 1994, Zhimulev et al., 1987)

Df(1)ras-v17

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)ras-v-P26

(Zhimulev et al., 1987)

Df(1)sbr8

(Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)sbr9

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v64f

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v65b

(Kozlova et al., 1994, Zhimulev et al., 1981)

Df(1)v-B151

(Zhimulev et al., 1987)

Df(1)v-L1

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Bgatov et al., 1986, Zhimulev et al., 1981)

Df(1)v-L2

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-L3

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev et al., 1981)

Df(1)v-L4

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-L7

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-L11

(Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-L15

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-M1

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-M5

(Kozlova et al., 1994, Pokholkova et al., 1991, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-M6

(Kozlova et al., 1994, Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-M7

(Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-P5

(Zhimulev et al., 1987, Zhimulev, 1982, Zhimulev et al., 1981)

Df(1)v-P16

(Kozlova et al., 1994)

Df(1)v-P22

(Kozlova et al., 1994, Zhimulev et al., 1987)

In(1)w^m4hrx500

(Kozlova et al., 1994)

Gene duplicated in

Dp(1;2)v⁺63i

(Zhimulev et al., 1987, Zhimulev et al., 1981)

Dp(1;2)v⁺65b

(Zhimulev et al., 1987, Geer et al., 1983)

Dp(1;2)v⁺75d

(Geer et al., 1983)

Dp(1;Y)v⁺y⁺

(Zhimulev et al., 1987, Geer et al., 1983, Zhimulev et al., 1981)

Dp(1;Y)v⁺y⁺U15

(Zhimulev et al., 1987)

Gene not duplicated in

Dp(1;Y)dsh⁺y⁺

(Zhimulev et al., 1987)

Dp(1;Y)v⁺y⁺366

(Zhimulev et al., 1987)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal

lethal | heat sensitive

lethal | recessive

lethal - all die before end of larval stage

costakink²³

lethal - all die before end of larval stage | recessive

costakink⁷

lethal - all die before end of pupal stage

costakink³³

lethal - all die before end of pupal stage | recessive

costakink³³

partially lethal | female

costakink¹

partially lethal - majority die

partially lethal - majority die | heat sensitive

viable

viable | male

costakink¹

Sterility

Allele

female semi-fertile

costakink¹

male fertile

costakink¹

Other Phenotypes

Allele

some die during larval stage

costakink²³

some die during larval stage | recessive

costakink⁷

some die during pupal stage

costakink³³

some die during pupal stage | recessive

costakink³³

visible

visible | recessive

costakink¹

Phenotype manifest in

Allele

costal vein

eye

costakink¹

wing

wing vein L1

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:costakink. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-33.0. 1-33.1

Cytogenetic map

10A2-10A2

Sequence location

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

10A2-10A2

Left limit from recombination mapping relative to v (FBrf0035977) Right limit from inclusion within Df(1)v64f (FBrf0035977)

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-33.13

(Geer et al., 1983)

1-33.4 +/- 1.0

(Fahmy and Fahmy, 1958)

1-33.0. 1-33.1

Left of (cM)

Hsp60A

(Zhimulev et al., 1981)

Right of (cM)

(Zhimulev et al., 1981)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (0)

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Most alleles are lethal; originally described on basis of a single surviving semi-lethal allele which displayed smaller eyes, with wings slightly reduced in size and abnormally held, with the costal vein frequently kinked near L2. Not fully penetrant; male viability and fertility good; female fertility reduced to about 50% wild type. Survivors of other semi-lethal or nearly lethal alleles display similar phenotype (Zhimulev, Pokholkova, Bgatov, Umbetova, Solovjeva, Khudyakov and Belyaeva, 1987). Lethal allele csk³³, functions in homozygous germ-line clones, but has no maternal effect (Perrimon, Engstrom and Mahowald, 1989). Fate maps, as a bilateral domineering mutant, to a broad region of the neurogenic ectoderm posterior to the metathoracic ganglion; in addition a nonautonomous focus in the wing disc gives rise to crumpled turned up wings (Bgatov, Zharkikh and Zhimulev, 1984).

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: costakink csk

(FlyBase, 2009-)

Nomenclature comments

The gene symbol "csk" has been changed to "costakink" in order to reduce confusion with the "Csk" ("C-terminal Src kinase") gene symbol, from which it differed only by case.

(FlyBase, 2009-)

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

(Lefevre and Watkins, 1986)

costakink

csk

(Skora and Spradling, 2010)

l(1)10Aa

(Kozlova et al., 1997, Kozlova et al., 1994)

l(1)10Ab

l(1)BP4

(Pokholkova et al., 1991, Zhimulev et al., 1987, Bgatov et al., 1986, Bgatov et al., 1984, Pokholkova and Zhimulev, 1984, Zhimulev, 1982, Zhimulev et al., 1981)

l(1)F120

l(1)G6

l(1)L68

l(1)dsS53

Name Synonyms

costakink

Secondary FlyBase IDs

FBgn0000381
FBgn0001481
FBgn0001482

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (19)

NA

Report Sections