FB2026_02 , released June 18, 2026
Gene: Ppyr\LUC
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General Information
Symbol
Ppyr\LUC
Species
P. pyralis
Name
Luciferase
Annotation Symbol
Feature Type
engineered_foreign_gene
FlyBase ID
FBgn0014448
Gene Model Status
Not Applicable
Stock Availability
27 publicly available
Gene Summary
Contribute a Gene Snapshot for this gene.
All Summaries
Also Known As

luc, Fluc, Pp-Luc

Foreign Gene Data

Foreign sequence; species == Photinus pyralis; gene == 'LUC'; UniProt:P08659.

(FlyBase Curators, 1992-)
Summaries
Alleles, Insertions, Transgenic Constructs
Classical and Insertion Alleles ( 20 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 171 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Ppyr\LUC
Transgenic constructs containing regulatory region of Ppyr\LUC
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
viable, with Scer\GAL4HD34A
Phenotype manifest in
Allele
Orthologs
Downloads
Download All DIOPT Orthologs
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Drosophila melanogaster (Fruit fly) (0)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    Functional Complementation Data
    Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
    Interactions
    Summary of Physical Interactions
    Interaction Browsers
    Summary of Genetic Interactions
    Interaction Browsers
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    Starting gene(s)
    Interaction type
    Interacting gene(s)
    Reference
    External Data
    Linkouts
    Class of Gene
    Stocks and Reagents
    Other Comments

    dsRNA has been made from templates generated with primers directed against this gene.

    (Rehwinkel et al., 2005)

    Double stranded RNA fragments have been used to study RNAi in Drosophila lysate based in vitro system.

    (Elbashir et al., 2001, Tuschl et al., 1999)

    per driven Ppyr\LUC reporter gene expression can be used to investigate transcriptional regulation of per and allows study of the molecular rhythmicity of an individual fly.

    (Plautz et al., 1997)

    A Ppyr\LUC reporter construct permits per circadian rhythms to be monitored by bioluminescence over several days in living adults.

    (Brandes et al., 1996)
    Relationship to Other Genes
    Source for database merge of
    Additional comments
    Nomenclature History
    Source for database identify of
    Nomenclature comments
    Etymology
    Synonyms and Secondary IDs (12)
    Reported As
    Symbol Synonym
    FL
    (Dorner et al., 2006)
    Fluc
    (Bronkhorst et al., 2014, Yagi et al., 2010, Yang et al., 2001)
    LUC
    (van Vickle-Chavez and van Gelder, 2007)
    Luc
    (Nagle et al., 2022, García-Alcover et al., 2014, Kramer et al., 2008, Mukherjee et al., 2006, Choi et al., 2004, Jin et al., 2004)
    Pp-Luc
    (Lipardi et al., 2001, Nykanen et al., 2001, Tuschl et al., 1999)
    Pp-luc
    (Elbashir et al., 2001)
    Ppyr\LUC
    luc
    (Goda et al., 2014, Ishimoto et al., 2009, Zheng et al., 2009, Wang et al., 2008, Acar et al., 2006, Bhaskara et al., 2006, Ratnaparkhi et al., 2006, Seto et al., 2006, Wright et al., 2006, Iijima-Ando et al., 2005, Moon et al., 2005, Mehren and Griffith, 2004, Park et al., 2004, Yoshida et al., 2004, Ghbeish et al., 2001)
    luciferase
    (Iijima-Ando et al., 2008)
    Name Synonyms
    Firefly luciferase
    (Dorner et al., 2006)
    Firefly-luciferas
    (Yagi et al., 2010)
    Luciferase
    (Bonchuk et al., 2011, Akasaka et al., 2006)
    luciferase
    (Zheng, 2019.3.1, Da Ros et al., 2013, Monnier et al., 2012, Monnier et al., 2012, Zheng et al., 2009, Isoo et al., 2007, Karres et al., 2007, Marr et al., 2007, Perrimon and Mathey-Prevot, 2007, Akasaka et al., 2006, Akasaka et al., 2006, Arbouzova et al., 2006, Bartscherer et al., 2006, Bhaskara et al., 2006, Chen, 2006, Chen et al., 2006, Chen et al., 2006, Fang et al., 2006, Glavan et al., 2006, Han et al., 2006, Han et al., 2006, Jafar-Nejad et al., 2006, Marr et al., 2006, Mosimann et al., 2006, Mukherjee et al., 2006, Ogden et al., 2006, Ulvila et al., 2006, Wright et al., 2006, Yao et al., 2006, Yu et al., 2006, DasGupta et al., 2005, Hombria et al., 2005, Hulf et al., 2005, Lai et al., 2005, Nybakken et al., 2005, Rehwinkel et al., 2005, Reinking et al., 2005, Sano et al., 2005, Stark et al., 2005)
    Secondary FlyBase IDs
      Datasets (0)
      Study focus (0)
      Experimental Role
      Project
      Project Type
      Title
      Study result (0)
      Result
      Result Type
      Title
      External Crossreferences and Linkouts ( 0 )
      References (363)