Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
545 (aa); 60 (kD predicted)
Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\asun using the Feature Mapper tool.
The 2.5 kb Mat89Bb transcript is expressed at high levels in ovaries and in 0-4 hour embryos, and at low levels in other stages and tissues, including testes. Mat89Bb transcripts are detected in nurse cells starting at stage S9, and are exported to the oocyte at stage S10. At stage S10, expression is also detected in follicle cells.
GBrowse - Visual display of RNA-Seq signalsView Dmel\asun in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: asun Mat89Bb
Mat89Bb is required for normal nucleus-centrosome coupling in primary spermatocytes and for the normal attachment between the nucleus and the basal body in postmeiotic spermatids. Mat89Bb is also required for the normal perinuclear localisation of dynein-dynactin complexes in both spermatocytes and spermatids.
The gene is named "asunder" (set aprt in position or space) based on the mutant phenotype of a striking loss of association between asters and the nucleus during prophase in primary spermatocytes.