FlyBase Gene Report: Dmel\CG31038

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CG31038 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

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Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 4 -- 6

anlage in statu nascendi

(Fisher et al., 2012)

anterior endoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

posterior ectoderm anlage

Comment: anlage in statu nascendi

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

dorsal pharyngeal muscle primordium

(Fisher et al., 2012)

longitudinal trunk visceral muscle primordium

(Fisher et al., 2012)

somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

trunk visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CG31038 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CG31038

View exonic expression by tissue for Dmel\CG31038

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051038

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43535/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051038

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051038

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051038

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31038

Flygut - An atlas of the Drosophila adult midgut

FBgn0051038

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CG31038

Stages(s) 4-6
Stages(s) 7-8
Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 10 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 4 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CG31038

Transgenic constructs containing regulatory region of CG31038

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

CG31038^EY02844

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CG31038^GD10141

viable, with Scer\GAL4^Mef2.PR

CG31038^GD10141

viable, with Scer\GAL4^pnr-MD237

CG31038^GD10141

Sterility

Allele

fertile

CG31038^EY02844

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (3)

Hsap\FAM89B

5 of 14

Yes

Hsap\FAM89A

4 of 14

Yes

Hsap\TRANK1

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (3)

Rnor\Fam89b

5 of 14

Yes

Rnor\Fam89a

3 of 14

Yes

Rnor\Trank1

1 of 14

Yes

Mus musculus (laboratory mouse) (3)

Mmus\Fam89b

5 of 14

Yes

Mmus\Fam89a

3 of 14

Yes

Mmus\Trank1

1 of 14

Yes

Xenopus tropicalis (Western clawed frog) (2)

Xtro\fam89a

2 of 13

Yes

Xtro\tlk2

1 of 13

Danio rerio (Zebrafish) (2)

Drer\fam89b

4 of 14

Yes

Drer\fam89a

3 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\AgaP_AGAP008197

1 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CG31038. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (1)

lmgB

4 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

FAM89B; family with sequence similarity 89 member B

5 of 14

616128

FAM89A; family with sequence similarity 89 member A

4 of 14

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68394

DroID - A comprehensive database of gene and protein interactions.

FBgn0051038

MIST (protein-protein) - An integrated Molecular Interaction Database

43535

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-99

Cytogenetic map

99C5-99C6

Sequence location

3R:29,877,059..29,903,231 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

99C5-99C6

Limits computationally determined from genome sequence between P{PZ}ncd⁰⁵⁸⁸⁴ and P{lacW}l(3)s2500^s2500

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-99

(FlyBase, 2016)

3-97.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (10)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

85446

w¹¹¹⁸; P{XP}CG31038^d05202

24042

w¹¹¹⁸; Mi{ET1}CG31038^MB03005

65497

w¹¹¹⁸; PBac{IT.GAL4}CG31038^1185-G4

36250

y¹ w^*; Mi{MIC}CG31038^MI01216

19658

y¹ w^67c23; P{EPgy2}CG31038^EY02844

66772

y¹ w^*; Mi{PT-GFSTF.2}CG31038^{MI01216-GFSTF.2}

NIG-Fly

15512R-2

P{NIG.15512R}2

HMJ22817

y¹ v¹; P{TRiP.HMJ22817}attP40/CyO

VDRC

v110531

P{KK113090}VIE-260B

v25655

w¹¹¹⁸; P{GD10141}v25655

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (46)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0051038

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0051038

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

CG31038 is required for os-induced Stat92E phosphorylation.

(Baeg et al., 2005)

S2-derived S2-NP cells are treated with dsRNA made from templates generated with primers directed against CG31038 to assess the role of this gene in Stat92E tyrosine phosphorylation.

(Baeg et al., 2005)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG15512 CG7854

(FlyBase Genome Annotators, 2002-2003)

Additional comments

Annotations CG15512 and CG7854 merged as CG31038 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG15512

(Stanyon et al., 2004)

CG31038

(National Institute of Genetics Fly Stocks, 2023-, Voutyraki et al., 2023, Clandinin and Owens, 2016-, Gene Disruption Project members, 2015-, Ashwal-Fluss et al., 2014, Wit et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Edwards et al., 2009, Keleman et al., 2009.8.5, Tomancak et al., 2007, Zeitlinger et al., 2007, Wijnen et al., 2006, Zimmermann et al., 2006)

CG7854

Name Synonyms

Secondary FlyBase IDs

FBgn0039716
FBgn0039717

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 65 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43535

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

A0ACA5YM07

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

A0ACA5YM07

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0051038

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43535/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0051038

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0051038

FlyMine - An integrated database for Drosophila genomics

FBgn0051038

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG31038

MARRVEL_MODEL - MARRVEL (model organism gene)

43535

Linkouts

BioGRID - A database of protein and genetic interactions.

68394

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0051038

DroID - A comprehensive database of gene and protein interactions.

FBgn0051038

DRSC - Results frm RNAi screens

FBgn0051038

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0051038

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0051038

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG31038

Flygut - An atlas of the Drosophila adult midgut

FBgn0051038

MIST (protein-protein) - An integrated Molecular Interaction Database

43535

References (36)

The following external sites may use different assemblies or annotations than FlyBase.

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Report Sections