FB2026_02 , released June 18, 2026
Gene: Dmel\lncRNA:mimi
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General Information
Symbol
Dmel\lncRNA:mimi
Species
D. melanogaster
Name
mimi
Annotation Symbol
CR31451
Feature Type
lncRNA_gene
FlyBase ID
FBgn0051451
Gene Model Status
Current
Stock Availability
None publicly available
Gene Summary
mimi (lncRNA:mimi) is a long-noncoding RNA expressed exclusively in the nervous system. Its expression levels are undetectable to very low during embryonic and larval stages, and very high in the adult brain. lncRNA:mimi is necessary for the formation of large neuronal granules marked by the protein stau, and its deletion in null mutants causes granule disassembly. Adult lncRNA:mimi mutant flies suffer from a shortened life span, age-dependent progressive motor decline, and display a loss of transcriptome signatures of neuronal maturity. [Date last reviewed: 2022-11-10] (FlyBase Gene Snapshot)
All Summaries
Key Links
Genomic Location
Cytogenetic map
95D4-95D4
Sequence location
Recombination map
3-82
RefSeq locus
NT_033777 REGION:23983503..23985065
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (3 terms)
Molecular Function (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables molecular condensate scaffold activity
inferred from direct assay
(Grzejda et al., 2022)
Terms Based on Predictions or Assertions (0 terms)
Biological Process (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
involved_in protein-RNA complex assembly
inferred from mutant phenotype
(Grzejda et al., 2022)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
is_active_in cytoplasmic ribonucleoprotein granule
inferred from direct assay
(Grzejda et al., 2022)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
    -
    Summaries
    Gene Snapshot
    mimi (lncRNA:mimi) is a long-noncoding RNA expressed exclusively in the nervous system. Its expression levels are undetectable to very low during embryonic and larval stages, and very high in the adult brain. lncRNA:mimi is necessary for the formation of large neuronal granules marked by the protein stau, and its deletion in null mutants causes granule disassembly. Adult lncRNA:mimi mutant flies suffer from a shortened life span, age-dependent progressive motor decline, and display a loss of transcriptome signatures of neuronal maturity. [Date last reviewed: 2022-11-10]
    Gene Group (FlyBase)
    LARGE CYTOPLASMIC STAUFEN RNP GRANULES -
    Large cytoplasmic Staufen ribonucleoprotein (RNAP) granules are a neuronal biomolecular condensate scaffolded by the long non-coding RNA lncRNA:mimi. (Adapted from FBrf0254644).
    Gene Model and Products
    Number of Transcripts
    2
    Number of Unique Polypeptides
    0

    Please see the JBrowse view of Dmel\lncRNA:mimi for information on other features

    To submit a correction to a gene model please use the Contact FlyBase form

    Protein Domains (via Pfam)
    Isoform displayed:
    Pfam protein domains
    InterPro name
    classification
    start
    end
    Protein Domains (via SMART)
    Isoform displayed:
    SMART protein domains
    InterPro name
    classification
    start
    end
    Structure
    Experimentally Determined Structures
    Crossreferences
    Comments on Gene Model

    Probable lncRNA gene; may encode small polypeptide(s).

    Gene model reviewed during 5.40

    Gene model reviewed during 5.49

    Transcript Data
    Annotated Transcripts
    Name
    FlyBase ID
    RefSeq ID
    Length (nt)
    lncRNA:mimi-RC
    FBtr0308922
    NR_048473
    1063
    lncRNA:mimi-RD
    FBtr0308923
    NR_048472
    1563
    Additional Transcript Data and Comments
    Reported size (kB)
    Comments
    External Data
    Crossreferences
    Sequences Consistent with the Gene Model
    Mapped Features

    Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\lncRNA:mimi using the Feature Mapper tool.

    External Data
    Crossreferences
    Linkouts
    Expression Data
    Testis-specificity index

    The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

    -0.77

    Transcript Expression
    RNA-seq
    Stage
    Tissue/Position (including subcellular localization)
    Reference
    adult stage
    head
    (Grzejda et al., 2022)
    adult central nervous system
    (Grzejda et al., 2022)
    adult head
    (Grzejda et al., 2022)
    Additional Descriptive Data

    lncRNA:mimi is exclusively restricted to the adult nervous system and constitutes one ofthe most highly expressed polyadenylated RNAs in the Drosophila head.

    (Grzejda et al., 2022)

    lncRNA:mimi-RC is restricted to the adult nervous system and is one of the most highly expressed polyadenylated RNAs in the Drosophila head.

    (Grzejda et al., 2022)
    Marker for
     
    Subcellular Localization
    CV Term
    Polypeptide Expression
    Additional Descriptive Data
    Marker for
     
    Subcellular Localization
    CV Term
    Evidence
    References
    is_active_in cytoplasmic ribonucleoprotein granule
    inferred from direct assay
    (Grzejda et al., 2022)
    Expression Deduced from Reporters
    High-Throughput Expression Data
    Associated Tools

    JBrowse - Visual display of RNA-Seq signals

    View Dmel\lncRNA:mimi in JBrowse
    Bulk Downloads
    RNA-Seq RPKM values for all genes
    Reference
    See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
    Developmental Proteome: Life Cycle
    Developmental Proteome: Embryogenesis
    External Data and Images
    Linkouts
    BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
    DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
    EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
    FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
    FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
    Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
    Images
    FlyBase Wiki
    Image Based Resources
    Alleles, Insertions, Transgenic Constructs, and Aberrations
    Classical and Insertion Alleles ( 1 )
    For All Classical and Insertion Alleles Show
     
    Other relevant insertions
    Transgenic Constructs ( 3 )
    For All Alleles Carried on Transgenic Constructs Show
    Transgenic constructs containing/affecting coding region of lncRNA:mimi
    Transgenic constructs containing regulatory region of lncRNA:mimi
    Aberrations (Deficiencies and Duplications) ( 1 )
    Inferred from experimentation ( 1 )
    Gene disrupted in
    Df(3R)Exel6196
    (Ryder, 2004.4.26)
    Inferred from location ( 7 )
    Variants
    Variant Molecular Consequences
    Alleles Representing Disease-Implicated Variants
    Phenotypes
    For more details about a specific phenotype click on the relevant allele symbol.
    Other Phenotypes
    Allele
    abnormal locomotor behavior | adult stage | progressive
    short lived
    Phenotype manifest in
    Allele
    adult brain
    ribonucleoprotein granule | adult stage
    Orthologs
    Downloads
    Download All DIOPT Orthologs
    Human Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Homo sapiens (Human) (0)
    Model Organism Orthologs (via DIOPT v9.1)
    Species\Gene Symbol
    Score
    Best Score
    Best Reverse Score
    Source
    Compara
    Domainoid
    eggNOG
    Hieranoid
    Homologene
    Inparanoid
    OMA
    OrthoDB
    OrthoFinder
    OrthoInspector
    orthoMCL
    Panther
    Phylome
    SonicParanoid
    Alignment
    Complementation?
    Transgene?
    Rattus norvegicus (Norway rat) (0)
    Mus musculus (laboratory mouse) (0)
    Xenopus tropicalis (Western clawed frog) (0)
    Danio rerio (Zebrafish) (0)
    Caenorhabditis elegans (Nematode, roundworm) (0)
    Anopheles gambiae (African malaria mosquito) (0)
    Arabidopsis thaliana (thale-cress) (0)
    Saccharomyces cerevisiae (Brewer's yeast) (0)
    Schizosaccharomyces pombe (Fission yeast) (0)
    Escherichia coli (enterobacterium) (0)
    Other Organism Orthologs (via OrthoDB)
    Data provided directly from OrthoDB:lncRNA:mimi. Refer to their site for version information.
    Paralogs
    Downloads
    Download All DIOPT Paralogs
    Paralogs (via DIOPT v9.1)
    Human Disease Associations
    FlyBase Human Disease Model Reports
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Evidence
      References
      Potential Models Based on Orthology ( 0 )
      Human Ortholog
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Allele
      Disease
      Interaction
      References
      Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
      Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
      Homo sapiens (Human)
      Gene name
      Score
      OMIM
      OMIM Phenotype
      DO term
      Complementation?
      Transgene?
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Summary of Genetic Interactions
      Interaction Browsers
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      External Data
      Linkouts
      DroID - A comprehensive database of gene and protein interactions.
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3R
      Recombination map
      3-82
      Cytogenetic map
      95D4-95D4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      95D4-95D4
      Limits computationally determined from genome sequence between P{PZ}l(3)0468404684 and P{PZ}Atg600096
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      Experimentally Determined Recombination Data
      Location

      3-82

      (FlyBase, 2016)

      3-82.5

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (0)
      Genomic Clones (20)
      cDNA Clones (28)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      Antibody Information
      Laboratory Generated Antibodies
       
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
          Other Comments

          Annotation CG31451 renamed CR31451 in release 5.40 of the genome annotation.

          (FlyBase Genome Annotators, 2011)

          Annotation CG31451 restored in release 5.32 of the genome annotation.

          (FlyBase Genome Annotators, 2010)

          Annotation CG31451 eliminated in release 5.15 of the genome annotation.

          (FlyBase Genome Annotators, 2009)

          New annotation (CG31451) in release 3 of the genome annotation.

          (FlyBase Genome Annotators, 2002-2003)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: CG31451 anon- EST:Posey277

          (Ashburner, 2004.6.30)

          Source for merge of: CG31451 BcDNA:GH16531

          (FlyBase, 1996-)
          Additional comments

          Source for merge of CG31451 BcDNA:GH16531 was a shared cDNA ( date:030728 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of

          Source for identity of: lncRNA:CR31451 CR31451

          (FlyBase, 2009-)

          Source for identity of: lncRNA:mimi lncRNA:CR31451

          (Grzejda et al., 2022)
          Nomenclature comments
          Etymology

          'mimi' is French for 'cute'.

          (Grzejda et al., 2022)
          Synonyms and Secondary IDs (9)
          Reported As
          Symbol Synonym
          BcDNA:GH16531
          CG31451
          (DeSalvo et al., 2014, FlyBase Genome Annotators, 2010, FlyBase Genome Annotators, 2009, Keleman et al., 2009.8.5)
          CR31451
          (Grzejda et al., 2022, Xie et al., 2021, FlyBase Genome Annotators, 2011)
          anon-EST:Posey277
          gh16531
          (Herold et al., 2003)
          lncRNA:CR31451
          lncRNA:mimi
          mimi
          (Grzejda et al., 2022)
          Name Synonyms
          long non-coding RNA::CR31451
          mimi
          Secondary FlyBase IDs
          • FBgn0027701
          • FBgn0063242
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 22 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms
          Other crossreferences
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          Linkouts
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          References (25)