FlyBase Gene Report: Dmel\snoRNA:CD18

General Information

Symbol

Dmel\snoRNA:CD18

Species

D. melanogaster

Name

C/D box small nucleolar RNA 18

Annotation Symbol

CR33663

Feature Type

C_D_box_snoRNA_gene

FlyBase ID

FBgn0065071

Gene Model Status

Current

Stock Availability

None publicly available

Gene Summary

C/D box small nucleolar RNA 18 (snoRNA:CD18) encodes a snoRNA that forms a ribonucleoprotein complex with the product of Fib to guide methylation of A2598 in 28SrRNA:CR45844. [Date last reviewed: 2024-05-16] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Interactive Fly

Also Known As

snoRNA:284

Key Links

Genomic Location

Cytogenetic map

6B1-6B1

Sequence location

X:6,531,635..6,531,747 [-]

Recombination map

1-17

RefSeq locus

NC_004354 REGION:6531635..6531747

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (0 terms)

Molecular Function (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Biological Process (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\snoRNA:CD18 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

RNA 2D structure (Predicted by RNAcentral) (RNAcentral entry URS0002A1489F)

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Supported by FBrf0159270, FBrf0157728

snoRNA annotation based on comprehensive analysis of C/D box snoRNAs in D. melanogaster; FBrf0259352

Gene model reviewed during 6.58

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

snoRNA:CD18-RA

FBtr0091642

NR_002462

113

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

AJ544004

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\snoRNA:CD18 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.61

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\snoRNA:CD18 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\snoRNA:CD18

View exonic expression by tissue for Dmel\snoRNA:CD18

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772495/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0065071

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0065071

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 0 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of snoRNA:CD18

Transgenic constructs containing regulatory region of snoRNA:CD18

Aberrations (Deficiencies and Duplications) ( 0 )

Inferred from experimentation ( 0 )

Inferred from location ( 24 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (0)

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:snoRNA:CD18. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

C_D_box_snoRNA_gene

(Sklias et al., 2024, Huttenhofer, 2003.2.4, Yuan et al., 2003)

nuclear_gene

(Huttenhofer, 2003.2.4, Yuan et al., 2003)

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

1-17

Cytogenetic map

6B1-6B1

Sequence location

X:6,531,635..6,531,747 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

6B1-6B1

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

1-17

(FlyBase, 2016)

1-18.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (0)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Genomic Clones (14)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (0)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

New annotation (CR33663) in release 4.2 of the genome annotation.

(FlyBase Genome Annotators, 2005)

Encoded in an intron of another gene.

(Yuan et al., 2003)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: snoRNA:Or-CD10 snoRNA:284

(Huang et al., 2005)

Source for identity of: snoRNA:CD18 snoRNA:Or-CD10

(Sklias et al., 2024)

Nomenclature comments

The nomenclature of genes encoding C/D box snoRNAs has been systematically revised.

(Sklias et al., 2024)

Etymology

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

CR33663

Dm-284

(Yuan et al., 2003)

DmOr_cd10(SnoR284)

(Huang et al., 2005)

chrX:6376887..6376991

(Will et al., 2013)

snoR284

(Huttenhofer, 2003.2.4)

snoRNA:284

(Bergman et al., 2006.8.16)

snoRNA:CD18

(Sklias et al., 2024)

snoRNA:Or-CD10

Name Synonyms

C/D box small nucleolar RNA 18

snoRNA:284

Secondary FlyBase IDs

FBgn0053663

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 11 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

3772495

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ544004

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

NR_002462

RNAcentral - A comprehensive ncRNA sequence collection representing all ncRNA types from a broad range of organisms

URS0002A1489F_7227

Other crossreferences

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

3772495/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0065071

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0065071

FlyMine - An integrated database for Drosophila genomics

FBgn0065071

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CR33663

MARRVEL_MODEL - MARRVEL (model organism gene)

3772495

Linkouts

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0065071

References (10)

The following external sites may use different assemblies or annotations than FlyBase.

-0.61

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