FlyBase Gene Report: HTLV-1\Tax

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Gene: HTLV-1\Tax

General Information

Symbol

HTLV-1\Tax

Species

D. Human T-lymphotropic virus 1

Name

Transactivator

Annotation Symbol

Feature Type

engineered_foreign_gene

FlyBase ID

FBgn0284397

Gene Model Status

Stock Availability

None publicly available

Gene Summary

Contribute a Gene Snapshot for this gene.

All Summaries

Alliance
Auto summary
Interactive Fly

Also Known As

Tax

Foreign Gene Data

Foreign sequence; species == Human T-lymphotropic virus 1; gene == 'Tax, Transactivator'.

(FlyBase Curators, 1992-)

Summaries

Alleles, Insertions, Transgenic Constructs

Classical and Insertion Alleles ( 0 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 1 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of HTLV-1\Tax

Transgenic constructs containing regulatory region of HTLV-1\Tax

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Other Phenotypes

Allele

visible, with Scer\GAL4^GMR.PFa

HTLV-1\Tax^UAS.Tag:MYC

Phenotype manifest in

Allele

embryonic/larval hemocyte, with Scer\GAL4^Pxn.PS

HTLV-1\Tax^UAS.Tag:MYC

eye, with Scer\GAL4^GMR.PFa

HTLV-1\Tax^UAS.Tag:MYC

interommatidial bristle, with Scer\GAL4^GMR.PFa

HTLV-1\Tax^UAS.Tag:MYC

ommatidium, with Scer\GAL4^GMR.PFa

HTLV-1\Tax^UAS.Tag:MYC

Orthologs

Downloads

Download All DIOPT Orthologs

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

HTLV-1-induced adult T-cell leukemia/lymphoma

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

HTLV-1\Tax^UAS.Tag:MYC

model of adult T-cell leukemia/lymphoma

CEA

(Akkouche et al., 2021, Shirinian et al., 2015)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

HTLV-1\Tax^UAS.Tag:MYC

model of adult T-cell leukemia/lymphoma

is ameliorated by Rel^GD1199

(Akkouche et al., 2021, Shirinian et al., 2015)

is ameliorated by dl^GD1238

(Shirinian et al., 2015)

is ameliorated by key^GD1249

(Shirinian et al., 2015)

is ameliorated by key^KK107280

(Shirinian et al., 2015)

is ameliorated by E(z)^HMS00066

(Akkouche et al., 2021)

is ameliorated by HTLV-1\HBZ^{UAS.Tag:MYC,Tag:polyHis}

(Akkouche et al., 2021)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

Class of Gene

engineered_foreign_gene

(FlyBase Curators, 1992-)

Stocks and Reagents

Stocks (0)

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (8)

Reported As

Symbol Synonym

HTLV-1\Tax

Tax

(Hleihel et al., 2018, Shirinian et al., 2015)

Tax-1

(Shirinian et al., 2015)

Tax1

(Harnish et al., 2021)

Zzzz\Tax-1

Name Synonyms

HTLV-1 Tax transactivator

(Shirinian et al., 2015)

Human T-cell lymphotropic virus type 1 (HTLV-1) Tax transactivator 1

(FlyBase Curators, 1992-)

Transactivator

Secondary FlyBase IDs

FBgn0284211
FBgn0283654

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 0 )

References (5)