In humans, multiple genes have been implicated in epileptic disorders; in addition, in some cases, a specific gene is implicated in multiple forms of the disease. This report is for the diseases described as developmental and epileptic encephalopathy (DEE), previously called epileptic encephalopathy, early infantile (EIEE). These are severe forms of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy; prognoses are poor. A list of DEE subtypes, as defined by OMIM, can be found by following the links in the "OMIM phenotypic series" section, below. A subset of these can be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.
[updated Feb. 2021 by FlyBase; FBrf0222196]