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General Information
Name
developmental and epileptic encephalopathy
FlyBase ID
FBhh0000302
Disease Ontology Term
Parent Disease
OMIM
Overview

In humans, multiple genes have been implicated in epileptic disorders; in addition, in some cases, a specific gene is implicated in multiple forms of the disease. This report is for the diseases described as developmental and epileptic encephalopathy (DEE), previously called epileptic encephalopathy, early infantile (EIEE). These are severe forms of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy; prognoses are poor. A list of DEE subtypes, as defined by OMIM, can be found by following the links in the "OMIM phenotypic series" section, below. A subset of these can be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.

[updated Feb. 2021 by FlyBase; FBrf0222196]

Disease Summary Information
Parent Disease Summary: developmental and epileptic encephalopathy
OMIM report
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
Disease synonyms
DEE
epileptic encephalopathy, early infantile
infantile epileptic encephalopathy
Ohtahara syndrome
Ortholog Information
Human gene(s) in FlyBase
    Other mammalian ortholog(s) used
      D. melanogaster Gene Information (0)
      Other Genes Used: Viral, Bacterial, Synthetic (0)
        Summary of Physical Interactions (0 groups)
        Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
        Alleles Representing Disease-Implicated Variants
        Genetic Tools, Stocks and Reagents
        Sources of Stocks
        Contact lab of origin for a reagent not available from a public stock center.
        Bloomington Stock Center Disease Page
        Selected mammalian transgenes
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila transgenes
        Allele
        Transgene
        Publicly Available Stocks
        RNAi constructs available
        Allele
        Transgene
        Publicly Available Stocks
        Selected Drosophila classical alleles
        Allele
        Allele class
        Mutagen
        Publicly Available Stocks
        References (2)