One of several diseases associated with defects in the human gene MYO7A, an unconventional myosin. See human disease model report for Usher syndrome, deafness, MYO7A-related (FBhh0000472). OMIM includes this disease in the phenotypic series deafness, autosomal dominant (FBhh0000467).
[updated Jan. 2017 by FlyBase; FBrf0222196]
[DEAFNESS, AUTOSOMAL DOMINANT 11; DFNA11](https://omim.org/entry/601317)
[MYOSIN VIIA; MYO7A](https://omim.org/entry/276903)
Autosomal dominant deafness 11 is a nonsyndromic form of progressive neurosensory hearing loss with postlingual onset. Some affected individuals have mild vestibular symptoms (summary by Sun et al., 2011; pubmed:21150918). [from MIM:601317; 2017.01.09]
Autosomal dominant deafness 11 (DFNA11) is caused by heterozygous mutation in the gene encoding myosin VIIA (MYO7A). [from MIM:601317; 2017.01.09]
The MYO7A gene encodes a protein classified as an unconventional myosin. Unconventional myosins are motor molecules with structurally conserved heads that move along actin filaments. Their highly divergent tails are presumed to be tethered to different macromolecular structures that move relative to actin filaments, thus enabling them to transport cargo (Weil et al., 1995; pubmed:7870171). [from MIM:276903; 2017.01.09]
Many to many: 2 human to 2 Drosophila; the other human gene is MYO7B.
