Human Disease Model Report: obesity, susceptibility to (postulated), SNCAIP-related

General Information

Name

obesity, susceptibility to (postulated), SNCAIP-related

FlyBase ID

FBhh0000743

Disease Ontology Term

obesity

Parent Disease

obesity, susceptibility to (fly models overview)

OMIM

Overview

The role played in the neural control of energy homeostasis by the human protein encoded by SNCAIP has been investigated in Drosophila. SNCAIP (synuclein alpha interacting protein, also called synphilin-1 or SP1) encodes a protein containing several protein-protein interaction domains and is known to interact with alpha-synuclein (SNCA) in neuronal tissue. No gene orthologous to SNCAIP has been identified in Drosophila.

UAS constructs driving the wild-type human Hsap\SNCAIP gene have been introduced into flies. Overexpression of Hsap\SNCAIP in neurons, but not peripheral cells, increased the body weight of flies, increased food intake but did not affect locomotor activity, and increased the levels of triacylglycerols (one of the major intracellular forms of stored energy in flies); Hsap\SNCAIP transgenic flies are more resistant to food deprivation.

[updated Feb. 2020 by FlyBase; FBrf0222196]

Disease Summary Information

Parent Disease Summary: obesity, susceptibility to (fly models overview)

Symptoms and phenotype

Obesity is an abnormal accumulation of body fat, usually 20% or more over an individual's ideal body weight. Obesity is associated with increased risk of illness, disability, and death. (http://medical-dictionary.thefreedictionary.com/obesity).

(FlyBase Curators, 2013-)

The development of obesity is recognized as having both genetic and environmental components (https://www.sciencelearn.org.nz/resources/203-obesity-genetic-or-environmental).

(FlyBase Curators, 2013-)

Specific Disease Summary: obesity, susceptibility to (postulated), SNCAIP-related

OMIM report

Human gene(s) implicated

Symptoms and phenotype

Genetics

Cellular phenotype and pathology

Molecular information

SNCAIP encodes a protein containing several protein-protein interaction domains, including ankyrin-like repeats, a coiled-coil domain, and an ATP/GTP-binding motif. The encoded protein interacts with alpha-synuclein (SNCA) in neuronal tissue and may play a role in the formation of cytoplasmic inclusions and neurodegeneration. Different isoforms resulting from alternative splicing appear to have different molecular functions and targets. [Gene Cards, SNCAIP; 2018.02.23]

(FlyBase Curators, 2013-)

External links