This report describes general characteristics of the group of diseases classified as spinocerebellar ataxia, autosomal recessive, with axonal neuropathy (SCAN). SCAN is a genetically heterogeneous disorder, with multiple genes and mapped loci. A listing of SCAN subtypes, as defined by OMIM, can be found in the table below, with links to more detailed reports for subtypes that have been investigated using fly models.
[updated Jul. 2020 by FlyBase; FBrf0222196]
Spinocerebellar ataxia with axonal neuropathy is an autosomal recessive neuromuscular disorder typically characterized by onset in the first or second decade of gait disturbance, slowly progressive distal muscle weakness, and axonal sensorimotor neuropathy with distal sensory impairment. [from MIM:218387, MIM:607250; 2020.07.14]
