Name
diabetes mellitus, insulin-dependent, IPC-blocking model
FlyBase ID
FBhh0001400
Disease Ontology Term
Parent Disease
The Drosophila insulin-like peptide genes (Ilp1 through Ilp8) are expressed in small clusters of insulin-producing cells (IPCs) in the brain. The IPCs appear to be functionally analogous to the human pancreatic islet beta cells. This report describes a Drosophila model of insulin-dependent diabetes mellitus based on blocking release of the insulin-like peptides, using targeted expression of Kir2.1 (FBto0000566) in the IPCs.
[updated Oct. 2021 by FlyBase; FBrf0222196]
Disease Summary Information
Disease Summary: diabetes mellitus, insulin-dependent, IPC-blocking model
Cellular phenotype and pathology
Other mammalian ortholog(s) used
D. melanogaster Gene Information
(0)
Other Genes Used: Viral, Bacterial, Synthetic (0)
Summary of Physical Interactions (0 groups)
Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
Alleles Representing Disease-Implicated Variants
