FB2026_03 , released September 17, 2026
Human Disease Model Report: diabetes/obesity, impact of parental disease
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General Information
Name
diabetes/obesity, impact of parental disease
FlyBase ID
FBhh0001547
Disease Ontology Term
Parent Disease
OMIM
Overview

Drosophila has been used as a model to study transgenerational phenotypic effects of parental hyperglycemia and/or obesity. Metabolic responses, feeding patterns, and cardiac function have been assessed in a wide variety of studies. Typically, parents are fed a high-sugar or high-fat diet and subsequent generations are raised on a standard diet. Although maternal contribution is more frequently assessed, a number of studies assess paternal contribution, or both.

[updated Dec. 2023 by FlyBase; FBrf0222196]

Disease Summary Information
Disease Summary: diabetes/obesity, impact of parental disease
OMIM report
Human gene(s) implicated
Symptoms and phenotype
Genetics
Cellular phenotype and pathology
Molecular information
External links
    Disease synonyms
    Ortholog Information
    Human gene(s) in FlyBase
      Other mammalian ortholog(s) used
        D. melanogaster Gene Information (0)
        Other Genes Used: Viral, Bacterial, Synthetic (0)
          Summary of Physical Interactions (0 groups)
          Alleles Reported to Model Human Disease (Disease Ontology) (0 alleles)
          Alleles Representing Disease-Implicated Variants
          Genetic Tools, Stocks and Reagents
          Sources of Stocks
          Contact lab of origin for a reagent not available from a public stock center.
          Bloomington Stock Center Disease Page
          Related mammalian, viral, bacterial, or synthetic transgenes
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila transgenes
          Allele
          Transgene
          Publicly Available Stocks
          RNAi constructs available
          Allele
          Transgene
          Publicly Available Stocks
          Selected Drosophila classical alleles
          Allele
          Allele class
          Mutagen
          Publicly Available Stocks
          References (19)