FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
dome, et
FlyBase ID
FBig0000095447
Interaction Network
Interactions Browser links
dome network
et network
Reported Interactions
FBrf0211466-1.coIP.WB
Reference
Makki et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
et 

Lat

bait

HA tag

dome 

Dome

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Makki et al., 2010)
FBrf0212202-2.coIP.WB
Reference
Kallio et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
et 

ET

bait

Myc tag

dome 

Dome

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was S2 cell line transfected with tagged et and dome constructs.

(Kallio et al., 2010)
FBrf0230821-3.coIP.WB
Reference
Fisher et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
dome 

Dome

bait

FLAG tag

et 

Et/Lat

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

dome and et can heterodimerize - this inhibits dome homodimerization to block JAK/STAT signaling.

(Fisher et al., 2016)

Source was cell extract of Kc167 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Fisher et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)