FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Dcr-2, AGO2
FlyBase ID
FBig0000096066
Interaction Network
Interactions Browser links
Dcr-2 network
AGO2 network
Reported Interactions
FBrf0162291-4.ENZ.WB
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Dcr-2 

DCR-2

enzyme

His tag

Dcr-2 

DCR-2

enzyme

His tag

AGO2 

AGO2

enzyme target
AGO2 

AGO2

enzyme target
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0211382-1.coIP.WB
Reference
Miyoshi et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
AGO2 

Ago2

bait

FLAG tag

Dcr-2 

Dicer2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Miyoshi et al., 2010)
FBrf0216979-1.coIP.WB
Reference
Cernilogar et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Dcr-2 

DCR2

bait
AGO2 

AGO2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was S2 cell line nuclear extracts.

(Cernilogar et al., 2011)

RNase treatment did not disrupt observed interaction.

(Cernilogar et al., 2011)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)