FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
ptc, ihog
FlyBase ID
FBig0000097304
Interaction Network
Interactions Browser links
ptc network
ihog network
Reported Interactions
FBrf0209607-1.coIP.WB
Reference
Zheng et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2R+
Participants
Corresponds to
Reported as
Role
Note
ihog 

Ihog

bait

HA tag

ihog 
ihog 
ptc 

ptc

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
ihog 
fibronectin type III domain 2
necessary binding region
ihog 
fibronectin type III domain 2
mutation decreasing interaction
aa 653-655

K653E, Q655E

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; bait produced from transfected construct; prey produced from transfected construct.

(Zheng et al., 2010)

Coexpression of ihog with ptc leads to redistribution of ptc protein from intracellular vesicles to the plasma membrane, as observed by fluorescence microscopy and cell surface biotinylation studies.

(Zheng et al., 2010)
FBrf0210906-3.coIP.WB
Reference
Yan et al., 2010
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
ptc 

Ptc

bait

GFP tag

ihog 

Ihog

prey

V5 tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Yan et al., 2010)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)