FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
barr, Cap-D2
FlyBase ID
FBig0000097385
Interaction Network
Interactions Browser links
barr network
Cap-D2 network
Reported Interactions
FBrf0187841-3.coIP.WB
Reference
Savvidou et al., 2005
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Cap-D2 

CAP-D2

bait
barr 

Barren

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryos of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Savvidou et al., 2005)
FBrf0208173-4.coIP.MS
Reference
D'Avino et al., 2009
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
barr 

Barren

bait

Protein A tag

Cap-D2 

Cap-D2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Positive control.

(D'Avino et al., 2009)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(D'Avino et al., 2009)
FBrf0212718-4.coIP.WB
Reference
Pek and Kai, 2011
Description
physical association
Assay
Collection
Source/Stage
ovary / femaleadult stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
barr 

Barr

bait

GFP tag

Cap-D2 

CAP-D2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was adult female ovaries of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Pek and Kai, 2011)
FBrf0214405-4.coIP.WB
Reference
Pek and Kai, 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
barr 

barr

bait
Cap-D2 

Cap-D2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait derived from endogenous gene; prey derived from endogenous gene.

(Pek and Kai, 2011)
FBrf0221447-12.coIP.A
Reference
Herzog et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Cap-D2 

Cap-D2

bait

Myc tag, [35]S label

barr 

Barren

prey

[35]S label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

In this assay, Cap-D2 interacts more strongly with barr (Cap-H) than with Cap-H2.

(Herzog et al., 2013)

Interaction in vitro; bait produced and labeled by in vitro translation; prey produced and labeled by in vitro translation.

(Herzog et al., 2013)
FBrf0221447-7.coIP.A
Reference
Herzog et al., 2013
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
barr 

Barren

bait

FLAG tag, [35]S label

Cap-D2 

Cap-D2

prey

[35]S label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

barr (Cap-H), but not Cap-H2, interacts with Cap-G in this assay.

(Herzog et al., 2013)

Interaction in vitro; bait produced and labeled by in vitro translation; prey produced and labeled by in vitro translation.

(Herzog et al., 2013)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (5)