FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Lar, ena
FlyBase ID
FBig0000097389
Interaction Network
Interactions Browser links
Lar network
ena network
Reported Interactions
FBrf0108074-11.ENZ.A
Reference
Description
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Lar 

Dlar

enzyme

GST tag

Lar 

Dlar

enzyme

GST tag

Lar 
Lar 
ena 

Ena

enzyme target

His tag, [32]P label

ena 

Ena

enzyme target

His tag, [32]P label

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction
FBrf0108074-5.PD.WB
Reference
Wills et al., 1999
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Lar 

Dlar

bait

GST tag

Lar 
ena 

Ena

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Lar 
PTP domain 2
sufficient binding region
aa 1738-2030

no interaction with PTP domain 1

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from S2 cell extract.

(Wills et al., 1999)
FBrf0108074-7.PD.WB
Reference
Wills et al., 1999
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Lar 

Dlar

bait

GST tag

Lar 
ena 

Ena

prey

His tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Lar 
PTP domains
sufficient binding region
aa 1452-2030
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey produced as a recombinant fusion protein in baculovirus system.

(Wills et al., 1999)

Purified ena binds to Lar, and weakly to Ptp10D.

(Wills et al., 1999)
FBrf0191320-5.coIP.WB
Reference
Johnson et al., 2006
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Lar 

LAR

bait

TAP tag

ena 

Ena

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Johnson et al., 2006)
FBrf0191320-6.coIP.WB
Reference
Johnson et al., 2006
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Kc167
Participants
Corresponds to
Reported as
Role
Note
Lar 

LAR

bait

TAP tag

ena 

Ena

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of Kc cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Johnson et al., 2006)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)