FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
Open Close
General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000097876
Interaction Network
Interactions Browser links
Pcl network
Su(z)12 network
Reported Interactions
FBrf0159213-1.coIP.WB
Reference
Description
physical association
Collection
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Pcl 

PCL

bait

SU(Z)12

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryonic nuclear extract of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

The 600 kDa PRC2 complex (E(z), esc, Su(z)12, Caf1) is also present in larger 1 MDa complexes that additionally contain Rpd3 and Pcl. The larger 1 MDa PRC2 complex is only observed in 0-16 hr embryos, not in 18-24 hr embryos.

The interaction of Pcl with Su(z)12 is detected only in 0-16 hr embryos, but not in 18-24 hr embryos.

Immunoprecipitation of Pcl from size fractionated extracts containing complexes of about 1 MDa in size.

FBrf0159213-18.coIP.WB
Reference
Description
physical association
Collection
Cell line used
Participants
Corresponds to
Reported as
Role
Note

SU(Z)12

bait
Pcl 

PCL

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was embryonic nuclear extract of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

The 600 kDa PRC2 complex (E(z), esc, Su(z)12, Caf1) is also present in larger 1 MDa complexes that additionally contain Rpd3 and Pcl. The larger 1 MDa PRC2 complex is only observed in 0-16 hr embryos, not in 18-24 hr embryos.

Immunoprecipitation of Su(z)12 from size fractionated extracts containing complexes of about 1 MDa in size.

FBrf0227292-567.TFIN
Description
physical association
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Pcl 
unspecified role
Pcl 
unspecified role
Pcl 
unspecified role
unspecified role
unspecified role
unspecified role
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2R+ cell line; proteins produced from transfected construct or endogenous gene.

HGScore = 49.8132

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)