FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Su(z)12
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General Information
Symbol
Dmel\Su(z)12
Species
D. melanogaster
Name
Su(z)12
Annotation Symbol
CG8013
Feature Type
protein_coding_gene
FlyBase ID
FBgn0020887
Gene Model Status
Current
Stock Availability
11 publicly available
Gene Summary
Su(z)12 (Su(z)12) is a member of the Polycomb group of genes with products involved in transcriptional silencing. Su(z)12 encodes a subunit of Polycomb repressive complex 2 (PRC2), where it is required for the histone methyltransferase activity that yields trimethylation of histone H3 on lysine 27 (H3-K27me3). [Date last reviewed: 2019-09-26] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Suppressor of zeste 12, l(3)76BDo, SUZ12

Key Links
Genomic Location
Cytogenetic map
76D4-76D4
Sequence location
Recombination map
3-46
RefSeq locus
NT_037436 REGION:19918242..19923462
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (12 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
contributes_to nucleosome binding
inferred from direct assay
(Nekrasov et al., 2005)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables chromatin DNA binding
inferred from biological aspect of ancestor with PANTHER:PTN000502888
(GO Reference Genome Project, 2011-)
enables DNA binding
non-traceable author statement
(Czermin et al., 2002)
Biological Process (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
involved_in negative regulation of response to gamma radiation
inferred from mutant phenotype
(Zhang et al., 2008)
involved_in neurogenesis
inferred from mutant phenotype
(Bello et al., 2007)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
involved_in facultative heterochromatin formation
inferred by curator from GO:0035098
(Ohno et al., 2008, Muller et al., 2002)
involved_in negative regulation of DNA-templated transcription
non-traceable author statement
(Czermin et al., 2002)
Cellular Component (5 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from direct assay
(Herz et al., 2012, Ohno et al., 2008, Czermin et al., 2002, Muller et al., 2002)
part_of histone methyltransferase complex
inferred from direct assay
(Ketel et al., 2005)
located_in nucleus
inferred from direct assay
(Klymenko et al., 2006, Czermin et al., 2002)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
located_in chromatin
non-traceable author statement
(Czermin et al., 2002)
part_of ESC/E(Z) complex
inferred from biological aspect of ancestor with PANTHER:PTN001476056
(GO Reference Genome Project, 2011-)
is_active_in nucleus
inferred from biological aspect of ancestor with PANTHER:PTN000502888
(GO Reference Genome Project, 2011-)
part_of RSC-type complex
inferred from biological aspect of ancestor with PANTHER:PTN000502889
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. (Q9NJG9)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Su(z)12 (Su(z)12) is a member of the Polycomb group of genes with products involved in transcriptional silencing. Su(z)12 encodes a subunit of Polycomb repressive complex 2 (PRC2), where it is required for the histone methyltransferase activity that yields trimethylation of histone H3 on lysine 27 (H3-K27me3). [Date last reviewed: 2019-09-26]
Gene Group (FlyBase)
POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT -
The Polycomb repressive complex 2 (PRC2) is a Polycomb group complex. Histone-lysine N-methyltransferase which trimethylates catalyzes the trimethylation of K27 of histone H3 (H3K27me3) which serves to recruit PRC1 and K9 of histone H3 (H3K9me3) and promotes heterochromatin formation. The PRC2 core may preferentially interact with Pcl or Jarid2 giving rise to variants. (Adapted from FBrf0188105 & FBrf0252799).
POLYCOMB REPRESSIVE COMPLEX 2, JARID2-JING VARIANT -
The Polycomb repressive complex 2 (PRC2) is a Polycomb group complex. Histone-lysine N-methyltransferase which trimethylates catalyzes the trimethylation of K27 of histone H3 (H3K27me3) which serves to recruit PRC1 and K9 of histone H3 (H3K9me3) and promotes heterochromatin formation. he PRC2 core may preferentially interact with Pcl or Jarid2 giving rise to variants. (Adapted from FBrf0188105 & FBrf0252799).
Protein Function (UniProtKB)
Polycomb group (PcG) protein. While PcG proteins are generally required to maintain the transcriptionally repressive state of homeotic genes throughout development, this protein is specifically required during the first 6 hours of embryogenesis to establish the repressed state. Component of the Esc/E(z) complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The Esc/E(z) complex is necessary but not sufficient for the repression of homeotic target genes, suggesting that the recruitment of the distinct PRC1 complex is also required.
(UniProt, Q9NJG9)
Summary (Interactive Fly)

Polycomb group -histone methyltransferase activity - constituent of polycomb PRC2 complex - functions in nucleosome binding of Drosophila PRC2 - essential for tri-methylation of the lysine 27 residue of histone H3

Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Su(z)12 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9NJG9)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
PDB - An information portal to biological macromolecular structures
Comments on Gene Model

Gene model reviewed during 5.44

Gene model reviewed during 5.45

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Su(z)12-RA
FBtr0074916
NM_143802
4098
855
Su(z)12-RB
FBtr0074917
NM_168826
3936
900
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Su(z)12-PA
FBpp0074685
95.3
855
7.28
NP_652059
AAF49094
Su(z)12-PB
FBpp0074686
100.1
900
9.19
Q9NJG9
NP_730465
AAN11641
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)

900 (aa); 105 (kD)

(Muller et al., 2002)
Comments
External Data
Subunit Structure (UniProtKB)

Component of the polycomb repressive complex 2 (PRC2, also known as the Esc/E(Z) complex), composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho (PubMed:12408863, PubMed:12408864). PRC2 associates with the accessory components Jarid2 and jing to form the PRC2 Jarid2-jing variant (PRC2.2) (PubMed:22354997). PRC2 may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis (PubMed:12408863, PubMed:12408864, PubMed:12697833). This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2 (Probable). The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (Probable).

(UniProt, Q9NJG9)
Crossreferences
InterPro - A database of protein families, domains and functional sites
PDB - An information portal to biological macromolecular structures
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(z)12 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.33

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
part_of ESC/E(Z) complex
inferred from direct assay
(Herz et al., 2012, Ohno et al., 2008, Czermin et al., 2002, Muller et al., 2002)
part_of histone methyltransferase complex
inferred from direct assay
(Ketel et al., 2005)
located_in nucleus
inferred from direct assay
(Klymenko et al., 2006, Czermin et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Su(z)12 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 17 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 13 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Su(z)12
Transgenic constructs containing regulatory region of Su(z)12
Aberrations (Deficiencies and Duplications) ( 27 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Act5C.PI
lethal, with Scer\GAL4insc-Mz1407
lethal | recessive
lethal - all die before end of larval stage | recessive
lethal - all die during embryonic stage | recessive
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Mef2.PR
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4tin.CΔ4
Other Phenotypes
Allele
abnormal cell cycle | oogenesis, with Scer\GAL4nanos.PG
abnormal mitotic cell cycle | somatic clone
abnormal neuroanatomy
abnormal neuroanatomy (with Su(z)122)
abnormal neuroanatomy (with Su(z)125)
abnormal neuroanatomy | larval stage, with Scer\GAL4insc-Mz1407
abnormal neuroanatomy | somatic clone
abnormal stress response | oogenesis, with Scer\GAL4nanos.PG
decreased cell number | somatic clone
increased cell number | male, with Scer\GAL4C587
long lived | dominant
majority die during embryonic stage | maternal effect, with JabbaUASp.VHH(GFP4), Scer\GAL4VP16.mat.αTub67C
some die during embryonic stage | recessive
some die during larval stage | recessive
suppressor of variegation | dominant, with In(1)wm4
visible, with Scer\GAL4Bx-MS1096
visible, with Scer\GAL4pnr-MD237
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage, with Scer\GAL4ey.PH
visible | adult stage, with Scer\GAL4nub.PK
visible | homeotic | pharate adult stage (with Su(z)123)
visible | homeotic | pharate adult stage (with Su(z)124)
visible | homeotic | pharate adult stage (with Su(z)125)
visible | somatic clone
Phenotype manifest in
Allele
antenna, with Scer\GAL4ey.PH
antenna (with Su(z)123)
antenna (with Su(z)125)
anterior crossvein, with Scer\GAL4en.PU
anterior crossvein, with Scer\GAL4nub.PK
cyst progenitor cell | increased number, with Scer\GAL4C587
dendrite & dendritic arborising neuron
dendrite & dendritic arborising neuron (with Su(z)122)
dendrite & dendritic arborising neuron (with Su(z)125)
dendrite & dendritic arborising neuron | somatic clone
dendrite & dorsal multidendritic neuron ddaC | somatic clone
egg | germline clone
embryonic abdominal segment | germline clone (with Df(3L)kto2)
embryonic head segment | germline clone (with Df(3L)kto2)
embryonic mesothoracic segment | germline clone (with Df(3L)kto2)
embryonic metathoracic segment | germline clone (with Df(3L)kto2)
embryonic prothoracic segment | germline clone (with Df(3L)kto2)
eye, with Scer\GAL4ey.PH
female germline stem cell, with Scer\GAL4nanos.PG
ganglion mother cell | larval stage, with Scer\GAL4insc-Mz1407
haltere | ectopic (with Su(z)123)
haltere | ectopic (with Su(z)125)
larval neuroblast | larval stage, with Scer\GAL4insc-Mz1407
leg | ectopic (with Su(z)123)
leg | ectopic (with Su(z)125)
mesonotum, with Scer\GAL4pnr-MD237
mesothoracic metatarsus (with Su(z)123)
mesothoracic metatarsus (with Su(z)125)
metathoracic metatarsus (with Su(z)123)
metathoracic metatarsus (with Su(z)125)
neuroblast | somatic clone
ovary | germline clone
sex comb | ectopic (with Su(z)123)
sex comb | ectopic (with Su(z)125)
wing, with Scer\GAL4Bx-MS1096
wing, with Scer\GAL4en.PU
wing (with Su(z)123)
wing (with Su(z)125)
wing | cell autonomous | somatic clone
wing | cell non-autonomous | somatic clone
wing | somatic clone
wing blade, with Scer\GAL4en.PU
wing hinge | cell non-autonomous | somatic clone
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (1)
Hsap\SUZ12
14 of 14
Yes
Yes
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (1)
Rnor\Suz12
12 of 14
Yes
Yes
Mus musculus (laboratory mouse) (1)
Mmus\Suz12
13 of 14
Yes
Yes
Xenopus tropicalis (Western clawed frog) (1)
Xtro\suz12
11 of 13
Yes
Yes
Danio rerio (Zebrafish) (2)
Drer\suz12a
13 of 14
Yes
Yes
Drer\suz12b
13 of 14
Yes
Yes
Caenorhabditis elegans (Nematode, roundworm) (0)
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP011881
8 of 12
Yes
Yes
Agam\AgaP_AGAP011882
6 of 12
No
Yes
Arabidopsis thaliana (thale-cress) (4)
Atha\EMF2
9 of 13
Yes
Yes
Atha\FIS2
8 of 13
No
Yes
Atha\VRN2
8 of 13
No
Yes
Atha\AT4G16810
7 of 13
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\NPL6
2 of 13
Yes
Yes
Scer\SWP82
1 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\rsc7
1 of 12
Yes
Yes
Spom\snf59
1 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Su(z)12. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 0 )
    Human Ortholog
    Disease
    Evidence
    References
    Modifiers Based on Experimental Evidence ( 1 )
    Allele
    Disease
    Interaction
    References
    Su(z)12JF01706
    ameliorates  brain cancer
    modeled by prosJF02308
    (Gaultier et al., 2022)
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    SUZ12; SUZ12 polycomb repressive complex 2 subunit
    14 of 14
    606245
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Su(z)12 - B-H2
      two hybrid array
      (Shokri et al., 2019)
      Su(z)12 - BuGZ
      two hybrid array
      (Shokri et al., 2019)
      Su(z)12 - Caf1-55
      chromatography technology, molecular weight estimation by staining, ion exchange chromatography, western blot, pull down, anti tag coimmunoprecipitation, x-ray crystallography, isothermal titration calorimetry, predetermined participant
      (Yuan et al., 2012, Nowak et al., 2011, Schmitges et al., 2011, Ketel et al., 2005, Nekrasov et al., 2005, Czermin et al., 2002)
      Su(z)12 - E(z)
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based, tandem affinity purification, Identification by mass spectrometry, molecular sieving, molecular weight estimation by staining, anti tag western blot, chromatography technology, enzymatic study, autoradiography, ion exchange chromatography, pull down
      (Wang et al., 2018, Kang et al., 2015, Rhee et al., 2014, Rai et al., 2013, Tie et al., 2012, Yuan et al., 2012, Margueron et al., 2009, Kurzhals et al., 2008, Ohno et al., 2008, Ketel et al., 2005, Nekrasov et al., 2005, Tie et al., 2003, Czermin et al., 2002, Muller et al., 2002)
      Su(z)12 - E2f1
      two hybrid array
      (Shokri et al., 2019)
      Su(z)12 - HDAC1
      anti tag coimmunoprecipitation, anti tag western blot, ion exchange chromatography, western blot, anti bait coimmunoprecipitation
      (Yuan et al., 2024, Tie et al., 2003, Czermin et al., 2002)
      Su(z)12 - His3
      cross-linking study, confirmation by molecular weight
      (Yuan et al., 2012)
      Su(z)12 - Hmg-2
      two hybrid array
      (Shokri et al., 2019)
      Su(z)12 - Jarid2
      anti tag coimmunoprecipitation, multidimensional protein identification technology
      (Herz et al., 2012)
      Su(z)12 - Pcl
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
      (Rhee et al., 2014, Tie et al., 2003)
      Su(z)12 - Scm
      tandem affinity purification, Identification by mass spectrometry
      (Kang et al., 2015)
      Su(z)12 - Su(var)205
      anti bait coimmunoprecipitation, western blot
      (Cabrera et al., 2015)
      Su(z)12 - Trl
      anti bait coimmunoprecipitation, Identification by mass spectrometry, western blot
      (Lomaev et al., 2017)
      Su(z)12 - bon
      anti tag coimmunoprecipitation, anti tag western blot
      (Godneeva et al., 2023)
      Su(z)12 - esc
      anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, molecular weight estimation by staining, peptide massfingerprinting, experimental knowledge based, pull down, ion exchange chromatography, molecular sieving, anti tag western blot, chromatography technology
      (Seif and Francis, 2024, Wang et al., 2018, Kang et al., 2017, Kang et al., 2015, Rhee et al., 2014, Rai et al., 2013, Yuan et al., 2012, Kurzhals et al., 2008, Ketel et al., 2005, Nekrasov et al., 2005, Tie et al., 2003, Czermin et al., 2002, Muller et al., 2002)
      Su(z)12 - escl
      molecular sieving, western blot, anti bait coimmunoprecipitation
      (Kurzhals et al., 2008)
      Su(z)12 - foxo
      two hybrid array
      (Shokri et al., 2019)
      Su(z)12 - piwi
      anti tag coimmunoprecipitation, anti tag western blot
      (Peng et al., 2016)
      Su(z)12 - schlank
      anti tag coimmunoprecipitation, anti tag western blot
      (Yuan et al., 2024)
      RNA-RNA
      Physical Interaction
      Assay
      References
      Su(z)12 - mir-34
      luminiscence technology
      (Robins et al., 2005)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Su(z)12
      enhanceable
      esc
      (Ma et al., 2018)
      Su(z)12
      enhanceable
      htt
      (Dietz et al., 2015)
      Su(z)12
      enhanceable
      Pcl
      (Ma et al., 2018)
      Pcl|Su(z)12
      suppressible
      Pgi
      (Ma et al., 2018)
      Pcl|Su(z)12
      suppressible
      Tpi
      (Ma et al., 2018)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      E2f1
      suppressible
      Su(z)12
      (Ji et al., 2012)
      esc
      enhanceable
      Su(z)12
      (Ma et al., 2018)
      Pcl
      enhanceable
      Su(z)12
      (Ma et al., 2018)
      rpr
      enhanceable
      Su(z)12
      (Harris et al., 2020)
      sens
      suppressible
      Su(z)12
      (Anderson et al., 2011)
      External Data
      Subunit Structure (UniProtKB)
      Component of the polycomb repressive complex 2 (PRC2, also known as the Esc/E(Z) complex), composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho (PubMed:12408863, PubMed:12408864). PRC2 associates with the accessory components Jarid2 and jing to form the PRC2 Jarid2-jing variant (PRC2.2) (PubMed:22354997). PRC2 may also associate with Pcl and HDAC1/Rpd3 during early embryogenesis (PubMed:12408863, PubMed:12408864, PubMed:12697833). This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2 (Probable). The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing (Probable).
      (UniProt, Q9NJG9 )
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      External Data
      Linkouts
      KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      3L
      Recombination map
      3-46
      Cytogenetic map
      76D4-76D4
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      76D4-76D4
      Limits computationally determined from genome sequence between P{lacW}l(3)L1243L1243&P{lacW}Mi-2j3D4 and P{PZ}eRF100103
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      76E-76F
      (Birve, 1999.5.7)
      76E-77B
      (determined by in situ hybridisation)
      (Birve and Rasmuson-Lestander, 1997)
      Experimentally Determined Recombination Data
      Location

      3-46

      (FlyBase, 2016)

      3-43.5

      (Comeron et al., 2012)

      3-49.5

      (Birve and Rasmuson-Lestander, 1994)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (11)
      Genomic Clones (13)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (34)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
        Drosophila Genomics Resource Center cDNA clones

        For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

        cDNA Clones, End Sequenced (ESTs)
        BDGP DGC clones
        Other clones
        RNAi and Array Information
        Linkouts
        DRSC - Results frm RNAi screens
        Antibody Information
        Laboratory Generated Antibodies
         

        polyclonal

        (Lomaev et al., 2017, Tie et al., 2003, Muller et al., 2002)
        Commercially Available Antibodies
         
        Cell Line Information
        Publicly Available Cell Lines
         
        Other Stable Cell Lines
         
          Other Comments

          Su(z)12 is required for normal neuroblast proliferation in postembryonic central nervous system development.

          (Bello et al., 2007)

          Su(z)12 is required for for the maintenance of dendritic fields in class IV dendrite arborisation (da) neurons.

          (Parrish et al., 2007)

          dsRNA has been made from templates generated with primers directed against this gene. RNAi of Su(z)12 causes an increase in branch number and an expansion of the receptive field of class I neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.

          (Parrish et al., 2006)

          Area matching Drosophila EST AA438961. This EST has sequence similarity to Human KIAA0160 gene.

          (Davies, 2001.3.15)
          Relationship to Other Genes
          Source for database merge of

          Source for merge of: Su(z)12 l(3)76BDo

          (Birve et al., 2001)

          Source for merge of: Su(z)12 CG8013

          (FlyBase, 1996-)
          Additional comments

          Source for merge of Su(z)12 CG8013 was sequence comparison ( date:000605 ).

          (FlyBase, 1996-)
          Nomenclature History
          Source for database identify of
          Nomenclature comments
          Etymology
          Synonyms and Secondary IDs (14)
          Reported As
          Symbol Synonym
          CG8013
          (Hosono et al., 2015, Ni et al., 2010.12.1, Ni et al., 2008, Klebes et al., 2005)
          SU(Z)12
          (Decourcelle et al., 2019, Wang et al., 2018, Bajusz et al., 2015, Bowman et al., 2014, Grossniklaus and Paro, 2014, Mulvey et al., 2014, Follmer et al., 2012, Tie et al., 2012, Mills, 2010, Wang et al., 2010, Tie et al., 2009, Joshi et al., 2008, Joshi et al., 2008, Kurzhals et al., 2008, Ohno et al., 2008, Schwartz and Pirrotta, 2007, Tegeling et al., 2007, Wang et al., 2006, Chopra and Mishra, 2005, Ketel et al., 2005, Tie et al., 2005, Czermin et al., 2002)
          SUZ12
          (Akkouche et al., 2021, Margueron and Reinberg, 2011, Margueron et al., 2009)
          Su(Z)12
          (Barbour et al., 2020, Monribot-Villanueva et al., 2017, Mason-Suares et al., 2013, Wen et al., 2012, Taylor-Harding et al., 2004)
          Su(z)
          (Aloia et al., 2013)
          Su(z)12
          (Martinez, 2025, Bamgbose and Tulin, 2024, Gilbert et al., 2024, Petrosky et al., 2024, Ridgway et al., 2024, Seif and Francis, 2024, Veneti et al., 2024, Wen et al., 2024, Yuan et al., 2024, Chan et al., 2023, Erokhin et al., 2023, Godneeva et al., 2023, McPherson et al., 2023, Pang et al., 2023, Yang et al., 2023, Fischer et al., 2022, Gaultier et al., 2022, Kamiyama and Niwa, 2022, Kang et al., 2022, Srinivasan et al., 2022, Wang et al., 2022, Wang et al., 2022, Chaouch and Lasko, 2021, Erokhin et al., 2021, Ponrathnam et al., 2021, Vidaurre and Chen, 2021, Chetverina et al., 2020, DeLuca et al., 2020, Kinser and Pincus, 2020, Kuroda et al., 2020, Meyer-Nava et al., 2020, Morgan and Shilatifard, 2020, Parkhitko et al., 2020, Berlandi et al., 2019, Bonnet et al., 2019, Cheutin and Cavalli, 2019, Jiang et al., 2019, Leatham-Jensen et al., 2019, Seller et al., 2019, Shokri et al., 2019, Yang et al., 2019, Dasari et al., 2018, Davis and Rebay, 2018, Gene Disruption Project members, 2018-, Kennerdell et al., 2018, Levis, 2018.8.30, Lv et al., 2018, Rojas-Ríos and Simonelig, 2018, Sadasivam and Huang, 2018, Song et al., 2018, Janssens et al., 2017, Kang et al., 2017, Lomaev et al., 2017, Sharma et al., 2017, Transgenic RNAi Project members, 2017-, Goto et al., 2016, Kahn et al., 2016, Lv et al., 2016, Peng et al., 2016, Piunti and Shilatifard, 2016, Bradley et al., 2015, Dequéant et al., 2015, Dietz et al., 2015, Ghasemi et al., 2015, Kang et al., 2015, Lee et al., 2015, Schertel et al., 2015, Singh and Mishra, 2015, Van Bortle et al., 2015, Yung et al., 2015, Chen et al., 2014, Gambetta and Müller, 2014, Gonzalez et al., 2014, McElroy et al., 2014, Bengani et al., 2013, Debruhl et al., 2013, Di Croce and Helin, 2013, Iovino et al., 2013, Rai et al., 2013, Vasanthi et al., 2013, Herz et al., 2012, Ji et al., 2012, Lanzuolo and Orlando, 2012, Stepanik and Harte, 2012, Touma et al., 2012, Yuan et al., 2012, Anderson et al., 2011, Cavalli, 2011, Chen et al., 2011, Davis et al., 2011, Jungreis, 2011.11.18, Kirilly et al., 2011, Neumüller et al., 2011, Nowak et al., 2011, Schmitges et al., 2011, Toku et al., 2011, Anholt and Williams, 2010, Cooper et al., 2010, Gan et al., 2010, Prabhakaran and Kelley, 2010, Chen and Rasmuson-Lestander, 2009, Classen et al., 2009, Gambetta et al., 2009, Gambetta et al., 2009, Chen et al., 2008, Chen et al., 2008, Lin et al., 2008, Oktaba et al., 2008, Zhang et al., 2008, Bello et al., 2007, de Ayala Alonso et al., 2007, Nekrasov et al., 2007, Parrish et al., 2007, Schuettengruber et al., 2007, Klymenko et al., 2006, Muller and Kassis, 2006, Papp and Muller, 2006, Parrish et al., 2006, Qi et al., 2006, Nekrasov et al., 2005, Sengupta et al., 2004, Tie et al., 2003)
          Su(z)12
          (Maeda and Karch, 2006)
          Suz(12)
          (Zhang et al., 2016)
          Suz12
          (Xiong et al., 2016)
          l(3)76BDo
          (Cooper et al., 2010, Zhu et al., 2005, Kehle et al., 1998)
          su(z)12
          (Harris et al., 2020, Ma et al., 2018, Prabhakaran and Kelley, 2010)
          Name Synonyms
          Su(z)12
          (Davis et al., 2011)
          Suppressor of zeste 12
          (Piunti and Shilatifard, 2016, McElroy et al., 2014, Herz et al., 2012, Classen et al., 2009, Chen et al., 2008, Bello et al., 2007, Schuettengruber et al., 2007, Tegeling et al., 2007, Muller and Kassis, 2006)
          Suppressor of zeste12
          (Maeda and Karch, 2006)
          Suppressor-of-zeste-12
          (Chen and Rasmuson-Lestander, 2009)
          Secondary FlyBase IDs
          • FBgn0025924
          • FBgn0036917
          Datasets (0)
          Study focus (0)
          Experimental Role
          Project
          Project Type
          Title
          Study result (0)
          Result
          Result Type
          Title
          External Crossreferences and Linkouts ( 49 )
          Sequence Crossreferences
          NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
          GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
          GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
          RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
          UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
          UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
          Other crossreferences
          AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
          BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
          DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
          EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
          FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
          FlyMine - An integrated database for Drosophila genomics
          InterPro - A database of protein families, domains and functional sites
          KEGG Genes - Molecular building blocks of life in the genomic space.
          MARRVEL_MODEL - MARRVEL (model organism gene)
          PDB - An information portal to biological macromolecular structures
          Linkouts
          BioGRID - A database of protein and genetic interactions.
          Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
          DroID - A comprehensive database of gene and protein interactions.
          DRSC - Results frm RNAi screens
          Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
          FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
          FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
          Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
          Flygut - An atlas of the Drosophila adult midgut
          FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
          iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
          Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
          KEGG Pathways - A collection of manually drawn pathway maps representing knowledge of molecular interaction, reaction and relation networks.
          MIST (genetic) - An integrated Molecular Interaction Database
          MIST (protein-protein) - An integrated Molecular Interaction Database
          Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
          References (235)