Suppressor of zeste 12, l(3)76BDo, SUZ12
Polycomb group -histone methyltransferase activity - constituent of polycomb PRC2 complex - functions in nucleosome binding of Drosophila PRC2 - essential for tri-methylation of the lysine 27 residue of histone H3
Gene model reviewed during 5.44
Gene model reviewed during 5.45
None of the polypeptides share 100% sequence identity.
900 (aa); 105 (kD)
Component of the Esc/E(z) complex, composed of Caf1-55, esc, E(z), Su(z)12, and possibly pho. The Esc/E(z) complex may also associate with Pcl and Rpd3 during early embryogenesis. This complex is distinct from the PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc, Su(z)2. The two complexes however cooperate and interact together during the first 3 hours of development to establish PcG silencing. Interacts with corto in vitro.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Su(z)12 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Su(z)12 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Su(z)12 is required for normal neuroblast proliferation in postembryonic central nervous system development.
Su(z)12 is required for for the maintenance of dendritic fields in class IV dendrite arborisation (da) neurons.
dsRNA has been made from templates generated with primers directed against this gene. RNAi of Su(z)12 causes an increase in branch number and an expansion of the receptive field of class I neurons. RNAi also causes defects in muscle, alterations in the number of MD neurons, defects in dendrite morphogenesis and reproducible defects in da dendrite development.
Area matching Drosophila EST AA438961. This EST has sequence similarity to Human KIAA0160 gene.