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General Information
Symbol
Dmel\Su(z)124
Species
D. melanogaster
Name
FlyBase ID
FBal0094493
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Nucleotide change:

C19922039T

Reported nucleotide change:

C?T

Amino acid change:

Q219term | Su(z)12-PA; Q219term | Su(z)12-PB

Reported amino acid change:

Q219term

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Amino acid replacement: Q219term.

Nucleotide substitution: C?T.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In

dendrite & dorsal multidendritic neuron ddaC | somatic clone

Detailed Description
Statement
Reference

Homozygous germline clones result in degeneration of the ovary prior to vitellogenic stages.

Single cell class IV dendrite arborisation (da) neuron clones that are homozygous for Su(z)124 show a range of dendritic defects in the third instar larva. Homozygous class IV ddaC clones show a significant reduction in dendrite branching and total dendritic length compared to controls.

Heterozygous larvae show no significant defects in dendrite morphology of class IV dendrite arborisation (da) neurons.

Eggs are not recovered from females carrying homozygous germ-line clones.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
Statement
Reference
Other
Statement
Reference
Phenotype Manifest In
Suppressor of
Statement
Reference
Other
Statement
Reference

Su(z)124/Su(z)12[+] has dendrite & dorsal multidendritic neuron ddaC phenotype

E(z)63, Su(z)124/Su(z)12[+] has dendrite & dorsal multidendritic neuron ddaC phenotype

Additional Comments
Genetic Interactions
Statement
Reference

The disorganised eye phenotype caused by expression of sensScer\UAS.cNa under the control of Scer\GAL4lz-gal4 is suppressed by Su(z)124.

Pc1/Su(z)124 double heterozygous larvae show dendritic defects in class IV dendrite arborisation (da) neurons; there is a significant reduction in the number of dendritic branchpoints.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Fails to complement
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
References (13)