FB2026_02 , released June 18, 2026
Complex: POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT
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General Information
Name
POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT
Species
D. melanogaster
Symbol
PRC2
FlyBase ID
FBgg0000280
Date last reviewed
2023-08-08
Number of members
5
Description
Description
The Polycomb repressive complex 2 (PRC2) is a Polycomb group complex. Histone-lysine N-methyltransferase which trimethylates catalyzes the trimethylation of K27 of histone H3 (H3K27me3) which serves to recruit PRC1 and K9 of histone H3 (H3K9me3) and promotes heterochromatin formation. The PRC2 core may preferentially interact with Pcl or Jarid2 giving rise to variants. (Adapted from FBrf0188105 & FBrf0252799).
Notes on Group

PRC2 may interact with various other factors giving rise to multiple PRC2-like complexes with differing activities (FBrf0220020, FBrf0228921 and FBrf0232732).

Source Material
The POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT Gene Group has been compiled using the following publication(s): Fischer et al., 2022, Kassis et al., 2017, Piunti and Shilatifard, 2016, Lanzuolo and Orlando, 2012, and Margueron and Reinberg, 2011 .
Key Gene Ontology (GO) terms
Molecular Function
histone H3K9 methyltransferase activity
histone H3K27 methyltransferase activity
Biological Process
heterochromatin formation
Cellular Component
ESC/E(Z) complex
Related Gene Groups
Parent group(s)
CHROMATIN MODIFYING COMPLEXES
POLYCOMB GROUP COMPLEXES
Members (5)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
External Data
Synonyms and Secondary IDs
Synonym(s)
PRC2
ESC/E(Z) Complex
Extra Sex Combs/Enhancer of Zeste complex
PRC2 complex
POLYCOMB REPRESSIVE COMPLEX 2 (CORE SUBUNITS)
POLYCOMB REPRESSIVE COMPLEX 2, PCL VARIANT
Secondary FlyBase ID(s)
References (6)