FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
Interacting Genes
FlyBase ID
FBig0000098275
Interaction Network
Interactions Browser links
Fmr1 network
Dscam1 network
Reported Interactions
FBrf0221678-1.coIP.PCR
Description
physical association
Collection
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

FMRP

bait

Dscam

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval brain of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

Fmr1 protein suppresses Dscam translation, but does not affect the level of Dscam RNA.

FBrf0221678-4.coIP.SEQ
Description
physical association
Collection
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

FMRP

bait

Dscam

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval brain of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

Fmr1 protein binds multiple Dscam isoforms with no substantial isoform bias observed.

Isoforms of Dscam RNA bound to Fmr1 protein were identified by high throughput pyrosequencing.

FBrf0221817-1.coIP.WB
Reference
Description
physical association
Collection
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Fmr1 

FMRP

bait

Dscam

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was larval brains of wild-type fly line; bait produced from endogenous gene; prey produced from endogenous gene.

Fmr1 null mutations result in a 49% increase in Dscam1 protein levels.

External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (2)