FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mof, lncRNA:roX2
FlyBase ID
FBig0000099319
Interaction Network
Interactions Browser links
mof network
lncRNA:roX2 network
Reported Interactions
FBrf0129699-5.coIP.PCR
Reference
Akhtar et al., 2000
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Schneider's-line-2
Participants
Corresponds to
Reported as
Role
Note
mof 

MOF

bait
lncRNA:roX2 

roX2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

The interaction of roX2 RNA with mof is not disrupted by high salt conditions that are sufficient to disrupt the mle-mof protein-protein interaction. This suggests that roX2 RNA can bind mof independently of mle.

(Akhtar et al., 2000)

mof specifically coimmunoprecipitates roX2 RNA, but not Hsp26 RNA. However, additional studies in this paper do show that mof can bind RNA non-specifically in vitro.

(Akhtar et al., 2000)

Source was cell extract of SL2 cell line; bait produced from endogenous gene; prey produced from endogenous gene.

(Akhtar et al., 2000)
FBrf0129699-8.coIP.PCR
Reference
Akhtar et al., 2000
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Schneider's-line-2
Participants
Corresponds to
Reported as
Role
Note
mof 

MOF

bait

HA tag

mof 
mof 
lncRNA:roX2 

roX2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
mof 
chromodomain
mutation disrupting interaction
aa 416

Y416D

mof 
chromodomain
mutation decreasing interaction
aa 426

W426G

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of SL2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Akhtar et al., 2000)
FBrf0160428-2.coIP.PCR
Reference
Buscaino et al., 2003
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-unspecified
Participants
Corresponds to
Reported as
Role
Note
mof 

MOF

bait
lncRNA:roX2 

roX2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was whole cell extracts; bait produced from endogenous gene; prey produced from endogenous gene.

(Buscaino et al., 2003)
FBrf0191180-6.coIP.NB
Reference
Mendjan et al., 2006
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mof 

MOF

bait

TAP tag

lncRNA:roX2 

roX2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Positive control.

(Mendjan et al., 2006)

Source was embryos of transgenic fly line; bait produced from tagged transgenic construct; prey produced from endogenous gene.

(Mendjan et al., 2006)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (3)