FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
erm, brm
FlyBase ID
FBig0000100720
Interaction Network
Interactions Browser links
erm network
brm network
Reported Interactions
FBrf0224411-1.coIP.WB
Reference
Koe et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
brm 

Brm

bait

FLAG tag

erm 

Erm

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Koe et al., 2014)
FBrf0224411-2.coIP.WB
Reference
Koe et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
erm 

Erm

bait

Myc tag

brm 

Brm

prey

FLAG tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

brm specifically interacts with erm but not pnt.

(Koe et al., 2014)

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Koe et al., 2014)
FBrf0224411-3.coIP.WB
Reference
Koe et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
erm 

Erm

bait

FLAG tag

erm 
erm 
brm 

Brm

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
erm 
N-terminal domain
sufficient binding region
aa 1-441
erm 
C-terminal domain
sufficient binding region
aa 332-611
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Koe et al., 2014)

brm binds the N-terminal half of erm more strongly than the C-terminal half.

(Koe et al., 2014)
FBrf0224411-4.PD.WB
Reference
Koe et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
erm 

Erm

bait

MBP tag

erm 
erm 
brm 

Brm

prey

Myc tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
erm 
N-terminal domain
sufficient binding region
aa 1-441
erm 
C-terminal domain
sufficient binding region
aa 332-611

weak binding

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Interaction in vitro; bait produced as a recombinant fusion protein in bacterial system; prey derived from transfected cell line extract.

(Koe et al., 2014)

brm binds the N-terminal half of erm more strongly than the C-terminal half.

(Koe et al., 2014)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)