FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mir-let7, cwo
FlyBase ID
FBig0000104304
Interaction Network
Interactions Browser links
mir-let7 network
cwo network
Reported Interactions
FBrf0226800-1.miR-mRNA.LUC
Reference
Chen et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mir-let7 

let-7

bait
cwo 

CWO

prey
cwo 
cwo 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
cwo 
3-prime UTR
sufficient binding region
cwo 
let-7 target site
necessary binding region
AACAACACUACCUCAG
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

luciferase reporter assay

(Chen et al., 2014)

Source was S2 cell line; bait produced from transfected construct; prey produced from transfected reporter construct.

(Chen et al., 2014)
FBrf0226800-2.miR-mRNA.PCR
Reference
Chen et al., 2014
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mir-let7 

let-7

bait
cwo 

CWO

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Overexpression of let-7 reduces cwo mRNA levels.

(Chen et al., 2014)

Source was S2 cell line; bait produced from transfected construct; prey produced from endogenous gene.

(Chen et al., 2014)
External Crossreferences and Linkouts ( 0 )
References (1)