FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Arl2, Tbcc
FlyBase ID
FBig0000104698
Interaction Network
Interactions Browser links
Arl2 network
Tbcc network
Reported Interactions
FBrf0231300-6.coIP.WB
Reference
Chen et al., 2016
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Arl2 

Arl2

bait

Venus tag

Arl2 
Arl2 
Tbcc 

TBCC

prey

HA tag

Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Arl2 
residue T30
mutation decreasing interaction
aa 30

T30N

Arl2 
residue Q70
mutation increasing interaction
aa 70

Q70L, 10-fold higher binding

Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Source was cell extract of S2 cell line; bait produced from transfected construct; prey produced from transfected construct.

(Chen et al., 2016)

TBCC preferentially binds the GTP-bound form of Arl2 (Q70L) over the GDP-bound form (T30N).

(Chen et al., 2016)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)