FB2026_02 , released June 18, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
mir-92b, Mef2
FlyBase ID
FBig0000104705
Interaction Network
Interactions Browser links
mir-92b network
Mef2 network
Reported Interactions
FBrf0219365-1.miR-mRNA.LUC
Reference
Chen et al., 2012
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mir-92b 

mir-92b

bait
mir-92b 
Mef2 

Mef2

prey
Mef2 
Mef2 
Mef2 
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Mef2 
3-prime UTR
sufficient binding region
Mef2 
mir-92b target site 1
necessary binding region
CCGUUUCCGGACCAGUGCAAUA
Mef2 
mir-92b target site 2
necessary binding region
UAAUUUGUAAUUCUGUGCAAUU
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

luciferase reporter assay

(Chen et al., 2012)

Source was S2 cell line; bait produced from transfected construct; prey produced from transfected reporter construct.

(Chen et al., 2012)
FBrf0219365-2.miR-mRNA.PCR
Reference
Chen et al., 2012
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 16
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mir-92b 

mir-92b

bait
Mef2 

Mef2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Mutation of mir-92b increases Mef2 mRNA levels.

(Chen et al., 2012)

Source was embryos of mutant fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Chen et al., 2012)
FBrf0219365-3.miR-mRNA.WB
Reference
Chen et al., 2012
Description
physical association
Assay
Collection
Source/Stage
organism / embryonic stage 16
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mir-92b 

mir-92b

bait
Mef2 

Mef2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Mutation of mir-92b increases Mef2 protein levels.

(Chen et al., 2012)

Source was embryos of mutant fly line; bait produced from endogenous gene; prey produced from endogenous gene.

(Chen et al., 2012)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)