FB2026_03 , released September 17, 2026
Physical Interaction report
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General Information
Interaction Type
physical association
Interacting Genes
Top2, mod(mdg4)
FlyBase ID
FBig0000104818
Interaction Network
Interactions Browser links
Top2 network
mod(mdg4) network
Reported Interactions
FBrf0213027-1.coIP.WB
Reference
Ramos et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
mod(mdg4) 

Mod(mdg4)2.2

bait
Top2 

Topo II

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

mod(mdg4) antibody used was raised against isoform designated mod(mdg4)2.2 (FBrf0136690), which corresponds to FlyBase isoform mod(mdg4)-PT (FBrf0083144); likely that antibody crossreacts with other mod(mdg4) isoforms.

(Ramos et al., 2011)
FBrf0213027-2.coIP.WB
Reference
Ramos et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
S2-DGRC
Participants
Corresponds to
Reported as
Role
Note
Top2 

Topo II

bait
mod(mdg4) 

Mod(mdg4)2.2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

mod(mdg4) antibody used was raised against isoform designated mod(mdg4)2.2 (FBrf0136690), which corresponds to FlyBase isoform mod(mdg4)-PT (FBrf0083144); likely that antibody crossreacts with other mod(mdg4) isoforms.

(Ramos et al., 2011)
FBrf0213027-3.Y2H
Reference
Ramos et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
Top2 

Topo II

bait
mod(mdg4) 

Mod(mdg4)2.2

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Prey was cloned reagent (previously isolated).

(Ramos et al., 2011)

Two-hybrid system: yeast GAL4-BD/GAL4-AD.

(Ramos et al., 2011)
FBrf0213027-4.Y2H
Reference
Ramos et al., 2011
Description
physical association
Assay
Collection
Source/Stage
Cell line used
Participants
Corresponds to
Reported as
Role
Note
mod(mdg4) 

Mod(mdg4)2.2

bait
Top2 

Topo II

prey
Experimental entities
Corresponds to
Identifier
Reported
Role
Note
Subregions with role in interaction
Corresponds to
Description
Role
Coordinates
Note
Isoform-specific participants
Corresponds to
Description
Role
Note
Comments concerning this interaction

Prey was cloned reagent (previously isolated).

(Ramos et al., 2011)

Two-hybrid system: yeast GAL4-BD/GAL4-AD.

(Ramos et al., 2011)
External Crossreferences and Linkouts ( 1 )
Linkouts
MIST - An integrated Molecular Interaction Database
References (1)